| چکیده انگلیسی مقاله |
Purpose: To report the evolving indications for keratoplasty and the shift in the technique of keratoplasty performed in Iran over an 8-year period. Methods: This was a retrospective database review of 47,129 records of corneal transplant tissues at the Central Eye Bank of Iran, from March 2006 to March 2013. The patient demographics, indications, and techniques of corneal transplantation performed were analyzed. Results: The six leading indications were keratoconus (KCN, n= 21,350 eyes, 45.3%), followed by bullous keratopathy (BK, n= 8,566 eyes, 18.2%), corneal opacity and scar (COS, n= 7,158 eyes, 15.2%), graft failure (n= 3,252 eyes, 6.9%), corneal dystrophies (n= 2,553 eyes, 5.4%), and infectious keratitis (n=2,238 eyes, 4.7%). Penetrating keratoplasty (PKP) accounted for 71.0% (n=33,476) of all keratoplasties performed. Since the introduction of Descemet stripping automated endothelial keratoplasty (DSAEK) in Iran in 2008, there was a significant increase in the number of DSAEK (P< 0. 001) and a statistical decline in the number of PKP (P< 0.005). No significant change was observed in the number of deep anterior lamellar keratoplasty (DALK), tectonic graft, and keratolimbal allograft (KLAL), during the 8-year period (P= 0.354, P= 0.999, and P= 0.151, respectively). An increasing trend in the frequencies of BK (P= 0.001) and graft failure (P= 0.025), and a decreasing trend in the frequency of COS (P= 0.012) were observed. No significant change of frequencies was noted in the prevalence of KCN (P= 0.172), infectious keratitis (P= 0.107), and corneal dystrophies (P= 0.836). Conclusion: KCN is still the leading indication for keratoplasty in Iran, with no significant change of trend over the 8-year period. There was an increasing trend in the rate of DSAEK while PKP demonstrated a decreasing trend; which indicates a shift from PKP to DSAEK performed for corneal endothelial disorders. |