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Iranian Journal of Medical Sciences، جلد ۳۲، شماره ۲، صفحات ۱۲۹-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Antibiotics and/or Chemotherapy on Generation of Reactive Oxygen Intermediate by Neutrophils |
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| چکیده انگلیسی مقاله |
Dear Editor, The O 2 -generating enzyme NADPH oxidase, plays a crucial role in host defense against microbial infection through the production of reactive oxygen species (ROS). 1 The multisubunit NADPH oxidase complex can be detected in vitro by the nitroblue tetrazolium test (NBT). 2 The NBT test is used for the diagnosis of chronic granulomatous disease. 3 However, several factors, such as some cytotoxic drugs and antibiotics can affect the results of this test. The impaired capability of neutrophils to reduce NBT from a patient treated for tuberculosis and non-Hodgkin's lymphoma, before the final diagnosis was made intrigued us to evaluate the NBT reduction test in that patient after completion of his treatment. Then, we observed a subsequent increase of the capability of Phorbol Myristic Acetate (PMA) stimulated NBT test. We therefore concluded that NBT test may not be useful for evaluation of ROS generation in neutrophils after chemotherapy and/or administration of antibiotics. This observation may be attributed either to the effect of immunosuppressive drugs which inhibit PMA-induced superoxide generation of neutrophils, 4 or the anti-inflammatory effects of antibiotics which can decrease the ability of ROS production from polymorphonuclear leukocytes. 5 |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
مریم آیت اللهی | maryam ayatollahi
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| نشانی اینترنتی |
http://ijms.sums.ac.ir/index.php/IJMS/article/view/1856 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Letter(s) to the Editor |
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