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Iranian Journal of Medical Sciences، جلد ۳۵، شماره ۴، صفحات ۳۰۴-۰
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عنوان انگلیسی The Effect of Cumin Seed Extracts against Herpes Simplex Virus Type 1 in Vero Cell Culture
چکیده انگلیسی مقاله Background: Cumin ( Cuminum cyminum L . [family Apiaceae]) seed essential oil is reported to have antiseptic activity. Until now the antiviral properties of cumin seed extracts on viruses such as herpes simplex virus-1 (HSV-1) have not been studied. The objective of this study was to investigate the in vitro effects of aqueous, methanolic and hydroalcoholic extracts of cumin seed on HSV-1 growth in Vero cell line. Methods: Antiviral activity of various concentrations aqueous, hydroalcoholic and methanolic extracts of cumin seed in Vero cells were studied using plaque reduction assays. The 50% cytotoxic concentration (CC 50 ), 50% inhibitory concentration (IC 50 ), and therapeutic index of the effective extracts were calculated. Results: Methanolic extract of cumin seed showed a significant antiviral activity on HSV-1 in Vero cell line. Its CC 50 for Vero cells, IC 50 and the therapeutic index for HSV-1 were 0.45, 0.18 mg/mL and 2.5, respectively. Aqueous and hydroalcoholic extracts of cumin seeds showed no inhibitory effect on HSV-1. Conclusion: The methanolic extract of cumin seed produces anti-HSV-1 effect. Probable interference of phenolic compounds with fusion of Vero cell membrane and HSV-1 envelope might be the mechanism of such inhibitory effect. Further studies are required to ascertain its in vivo antiviral properties and potential toxicity.
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نویسندگان مقاله محمد معتمدی فر | mohammad motamedifar


نرجس غفاری | narjes ghafari


پدرام طالع زاده شیرازی | pedram talezadeh shirazi


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/1547
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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