این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
گوارش، جلد ۹، شماره ۱، صفحات ۵-۰
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عنوان انگلیسی Impact of Immunosuppressive Treatment on Liver Fibrosis in Autoimmune Hepatitis
چکیده انگلیسی مقاله Introduction and Aims: Impact of treatment on progression of fibrosis in autoimmune hepatitis (AIH) is unknown. We assessed the changes in liver fibrosis before and after treatment among these patients. Materials and Methods: Nineteen AIH patients who had paired liver biopsies were studied. Of these, seven had been treated with 6 months of Cyclosporine-A and the rest with 6 months of prednisolone for induction of remission. Thereafter all had been maintained on azathioprine. Biopsy specimens before and after treatment, were reviewed by one pathologist and scored by the Ishak method. Mean fibrosis stage before and after treatment were compared. Also, factors predicting significant fibrosis (stage ≥3) and cirrhosis (stage ≥5) at presentation were assessed. Results: Mean interval between biopsies was 3.38 years. Mean fibrosis stage decreased from 4.53 to 2.16 following treatment (p‹ 0.001). Mean decrement in inflammatory grade was 8 scores (range: 4-10) in patients in whom fibrosis improved, and 2 scores (range: 0-4) in patients in whom fibrosis did not decrease after treatment (p‹ 0.001). ALT to platelet ratio was the best predictor of significant fibrosis and also cirrhosis. Conclusions: Fibrosis commonly improves after immunosuppressive treatment in AIH. ALT to Platelet ratio can predict accurately the presence of significant fibrosis and cirrhosis in AIH.
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نویسندگان مقاله ناصر رخشانی | nasser rakhshani


مهدی محمدنژاد | mehdi mohamadnejad


سیاوش ناصری مقدم | siavosh nasseri moghaddam


سید میثم علی محمدی | seyedmeysam alimohamadi


سپیده فرزامی آزالی | sepideh hagh azali


سید محمد توانگر | seyedmohammad tavangar


رضا ملک زاده | reza malekzadeh


نشانی اینترنتی http://www.govaresh.org/index.php/dd/article/view/969
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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