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Hepatitis Monthly، جلد ۱۳، شماره ۵، صفحات ۰-۰
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| عنوان فارسی |
Prevalence of Occult Hepatitis B Virus in Plasma and Peripheral Blood Mononuclear Cell Compartments of Patients With Chronic Hepatitis C Infection in Tehran-Iran |
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| چکیده فارسی مقاله |
Conclusions In conclusion, occult HBV was found in 36% of patients with negative results for HBsAg, but positive results for HCV. Detection of HBV-DNA in both PBMCs and plasma together in comparison with plasma alone provided more true identification of OBI.The SVR rate was significantly higher in coinfected patients than mono-infected ones. Background Occult hepatitis B virus (HBV) infection (OBI) is frequently reported in patients with chronic hepatitis C virus (HCV) infection. An association between OBI and more liver damage, cirrhosis, hepatocellular carcinoma, and reduced response to interferon therapy in patients with HCV infection is suggested. Results HBV-DNA was detected using nested-PCR in 20% of plasma and 32.6% of peripheral blood mononuclear cell (PBMC) compartments. No significant differences were observed between patients with and without occult HBV for sex, age, duration of HCV infection, histological markers, presence of anti-HBc, HCV viral load, and HCV genotype. The response rate was significantly higher in patients with positive results for HBV-DNA test compared to those with negative findings (100% vs. 71.9 %, P < 0.05). Objectives The aim of this study was to determine the prevalence of occult HBV, and evaluate its clinical influence on patients with chronic HCV. Patients and Methods A cohort study including50 patients with positive results for HCV, and negative results for HBsAg tests was performed. The patients were divided into two groups: one group had positive results for both HCV and occult HBV tests (n = 18), and the other had positive results for HCV, but negative findings for occult HBV (n = 32). All were treated with PEG-IFN alpha-2a and Ribavirin. Presence of HCV RNA was followed in these patients. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Prevalence of Occult Hepatitis B Virus in Plasma and Peripheral Blood Mononuclear Cell Compartments of Patients With Chronic Hepatitis C Infection in Tehran-Iran |
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| چکیده انگلیسی مقاله |
Conclusions In conclusion, occult HBV was found in 36% of patients with negative results for HBsAg, but positive results for HCV. Detection of HBV-DNA in both PBMCs and plasma together in comparison with plasma alone provided more true identification of OBI.The SVR rate was significantly higher in coinfected patients than mono-infected ones. Background Occult hepatitis B virus (HBV) infection (OBI) is frequently reported in patients with chronic hepatitis C virus (HCV) infection. An association between OBI and more liver damage, cirrhosis, hepatocellular carcinoma, and reduced response to interferon therapy in patients with HCV infection is suggested. Results HBV-DNA was detected using nested-PCR in 20% of plasma and 32.6% of peripheral blood mononuclear cell (PBMC) compartments. No significant differences were observed between patients with and without occult HBV for sex, age, duration of HCV infection, histological markers, presence of anti-HBc, HCV viral load, and HCV genotype. The response rate was significantly higher in patients with positive results for HBV-DNA test compared to those with negative findings (100% vs. 71.9 %, P < 0.05). Objectives The aim of this study was to determine the prevalence of occult HBV, and evaluate its clinical influence on patients with chronic HCV. Patients and Methods A cohort study including50 patients with positive results for HCV, and negative results for HBsAg tests was performed. The patients were divided into two groups: one group had positive results for both HCV and occult HBV tests (n = 18), and the other had positive results for HCV, but negative findings for occult HBV (n = 32). All were treated with PEG-IFN alpha-2a and Ribavirin. Presence of HCV RNA was followed in these patients. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
زینب وکیلی ghartavol | zeinab vakili ghartavol
department of basic sciences, science and research branch, islamic azad university, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
سید موید علویان | seyed moayed alavian
baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences and tehran hepatitis center, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)
صفیه امینی | safieh amini
department of hepatitis and aids, pasteur institute of iran, tehran, ir iran; department of hepatitis andaids, pasteur institute of iran, tehran, ir iran. tel 98-2166969291, fax 98-2166969291
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)
روح اله وهاب پور | rouhollah vahabpour
department of hepatitis and aids, pasteur institute of iran, tehran, ir iran; department of virology, tehran university of medical sciences, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
گلناز بهرامعلی | golnaz bahramali
department of hepatitis and aids, pasteur institute of iran, tehran, ir iran
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)
احسان مصطفوی | ehsan mostafavi
department of epidemiology, pasteur institute of iran, tehran, ir iran
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)
محمدرضا آقاصادقی | mohammad reza aghasadeghi
department of hepatitis and aids, pasteur institute of iran, tehran, ir iran
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)
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| نشانی اینترنتی |
http://www.hepatmon.com/index.php?page=article&article_id=10134 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.5812/hepatmon.10134 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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