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Iranian Biomedical Journal، جلد ۱۳، شماره ۲، صفحات ۱۰۳-۱۰۸
عنوان فارسی بررسی پلی مورفیسم های I۴۰۵V و -۶۲۹C/A از ژن پروتئین انتقال دهنده کلستریل استر در بیماران عروق کرونر
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عنوان انگلیسی I405V and -629C/A Polymorphisms of the Cholesteryl Ester Transfer Protein Gene in Patients with Coronary Artery Disease
چکیده انگلیسی مقاله Background: Cholesteryl ester transfer protein (CETP) plays a main role in high-density lipoprotein metabolism. CETP gene possesses several single nucleotide polymorphisms which have been associated with plasma high-density lipoprotein cholesterol (HDL-C) concentrations. The aim of this study was to determine the association of CETP -629C/A and I405V polymorphisms with coronary artery disease (CAD) in Iranian population. Methods: The presence of two CETP gene polymorphisms -629C/A and I405V were studied in 187 unrelated CAD cases and 136 controls. All the samples were clinically examined and lipid profile was estimated. Genotyping was performed using polymerase chain reaction/restriction fragment length polymorphism method. Results: The frequency of -629C/A and I405V allelic variants were found to be 0.732 and 0.366 in cases and 0.658 and 0.348 in controls, respectively. The frequency of A allele of -629C/A polymorphism in cases was significantly higher than that of controls. HDL-C in AA genotype was higher than CA and CC genotypes in controls. No significant effect of II, IV and VV genotypes was found in lipid profiles. Conclusion: No significant association was found between CETP I405V polymorphism and increased risk of CAD in Azeri population studied. AA genotype of -629C/A increased HDL but the risk of CAD in this genotype might be higher than CC genotype.
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نویسندگان مقاله کیهان قطره ثمانی | keihan ghatreh samani


محمد نوری | mohammad noori


محمد رهبانی نوبر | mohammad rohbani nobar


مرتضی هاشم زاده چالشتری | morteza hashemzadeh chaleshtori


عفت فرخی | effat farrokhi


مسعود دارابی امین | masoud darabi amin


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-27&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
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