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Iranian Biomedical Journal، جلد ۱۶، شماره ۲، صفحات ۹۰-۱۰۰
عنوان فارسی تاثیرات والپروئیک اسید به عنوان مهار کننده داستیلیشن هیستونی بر روی بهبودی رفتار های حرکتی موش های ضایعه نخاعی مدل کانتیوژن بر پایه علم اپی ژنتیک
چکیده فارسی مقاله
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عنوان انگلیسی Effects of Valproic Acid, a Histone Deacetylase Inhibitor, on improvement of Locomotor Function in Rat Spinal Cord Injury Based on Epigenetic Science
چکیده انگلیسی مقاله Background: The primary phase of traumatic spinal cord injury (SCI) starts by a complex local inflammatory reaction such as secretion of pro-inflammatory cytokines from microglia and injured cells that substantially contribute to exacerbating pathogenic events in secondary phase. Valproic acid (VPA) is a histone deacetylase inhibitor. Acetylation of histones is critical to cellular inflammatory and repair processes. Methods: In this study, rats were randomly assigned to five experimental groups (laminectomy, untreated, and three VPA-treated groups). For SCI, severe contusion was used. In treated groups, VPA was administered intraperitoneally at doses of 100, 200 and 400 mg/kg daily three hours after injury for 7 days. To compare locomotor improvement among experimental groups, behavioral assessments were performed by the Basso, Beattie and Bresnahan (BBB) rating scale. The expression of neurotrophins was evaluated by RT-PCR and real-time PCR. Results: VPA administration increased regional brain-derived neurotrophic factor and glial cell-derived neurotrophic factor mRNA levels. Local inflammation and the expression of the lysosomal marker ED1 by activated macrophages/microglial cells were reduced by VPA and immunoreactivity of acetylated histone and microtubule-associated protein were increased. Conclusion: The results showed a reduction in the development of secondary damage in rat spinal cord trauma with an improvement in the open field test (BBB scale) with rapid recovery.
کلیدواژه‌های انگلیسی مقاله Inflammation, Epigenetics, Valproic acid (VPA)
نویسندگان مقاله علیرضا عبدانی پور | alireza abdanipour


hermann j schluesener | hermann j schluesener


تقی طریحی | taki tiraihi


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-362&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده مقاله کامل
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