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Iranian Biomedical Journal، جلد ۱۶، شماره ۳، صفحات ۱۶۸-۱۶۲
عنوان فارسی ترکیب اسیدهای چرب فسفولیپیدهای مایع فولیکولی انسانی و میزان باروری در روش های کمک باروری
چکیده فارسی مقاله
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عنوان انگلیسی Fatty Acid Composition of Human Follicular Fluid Phospholipids and Fertilization Rate in Assisted Reproductive Techniques
چکیده انگلیسی مقاله Background: Fatty acids are known to be critically important in multiple biological functions. Phospholipid fatty acids of follicular fluid, an important microenvironment for the development of oocytes, may contribute to the women’s fertility and the efficacy of assisted reproduction techniques. The aim of this study was to investigate the effect of fatty acid composition of follicular fluid phospholipids on women undergoing assisted reproductive techniques. Methods: Follicular fluid samples were obtained from 100 patients, referred to Tabriz Alzahra Hospital. Seventy-nine subjects underwent in vitro fertilization (IVF) and the remaining 21 underwent intracytoplasmic sperm injection (ICSI). Total lipid of follicular fluid was extracted and fatty acids were analyzed by gas-liquid chromatography. Results: Saturated fatty acids (SFA, P = 0.002) and the ratio of SFA to polyunsaturated fatty acids (P = 0.001) were correlated negatively with a number of mature oocytes after age adjustment. Linoleic acid (P = 0.006) was positively correlated, while the level of arachidonic acid was negatively correlated with fertility percentage after adjustment for body mass index, sperm count, sperm motility. Conclusion: Since phospholipids are one of the major components of lipid metabolism, the results of this study highlight the importance of this component in follicular fluid lipid metabolism. Consequently, it is proposed as an index in determination of the rate of success in assisted reproductive techniques such as IVF/ICSI.
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نویسندگان مقاله مقصود شاکر | maghsod shaaker


علی رحیمی پور | ali rahimipour


محمد نوری | mohammad nouri


کوروش خانکی | korosh khanaki


مسعود دارابی | masoud darabi


لعیا فرزدی | laya farzadi


وحیده شهنازی | vahideh shahnazi


امیر مهدی زاده | amir mehdizadeh


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-364&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
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