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Iranian Biomedical Journal، جلد ۱۶، شماره ۴، صفحات ۲۱۸-۲۲۲
عنوان فارسی نقش پلیمرفیسم Ile۳۴۳۴Thr ژن XRCC۷ در احتمال سرطان تیروئید تمایز یافته در یک جمعیت ایرانی
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عنوان انگلیسی The role of Ile3434Thr XRCC7 gene polymorphism in Differentiated Thyroid Cancer risk in an Iranian population
چکیده انگلیسی مقاله Background: The aim of this study was to understand any association between differentiated thyroid carcinoma (DTC) and Ile3434Thr XRCC7 gene polymorphism (GenBank accession number: rs7830743). DTC is the most prevalent thyroid neoplasm, which includes papillary and follicular cell carcinoma. XRCC7 gene encodes a protein that functions in non-homologous end joining DNA repair pathway. Non-synonymous polymorphisms in this gene may alter DNA repair capacity of the cell and change the risk of developing cancers. Methods: DTC patients (n = 173) and cancer free individuals (n = 204) were enrolled in a case-control study. The Ile3434Thr polymorphic alleles were discriminated by using amplification refractory mutation system-PCR method. The frequencies of this single nucleotide polymorphism in case and control groups were compared. Also, risk ratio for developing DTC in dichotomized genotypes was estimated by multivariate logistic regression analysis. Results: Dichotomized genotypes into those with and without the 3434Thr allele showed that this allele was associated with DTC (OR [odd ratio]: 1.89, 95% confidence interval (CI) = 1.29-2.79, P< 0.001). Also, TC genotype was significantly associated with increased risk of DTC (OR: 2.42, 95% CI = 1.55-3.81, P = 0.0001) in individuals carrying this genotype. Conclusion: Allele 3434Thr in XRCC7 gene might be associated with differentiated thyroid cancer risk. Further studies with larger samples are needed to verify these initial findings.
کلیدواژه‌های انگلیسی مقاله DNA repair enzymes, Thyroid neoplasms, Genetic polymorphism
نویسندگان مقاله مریم رحیمی | maryam rahimi


شیما فیاض | shima fayaz


ارمغان فرد اصفهانی | armaghan fard esfahani


محمد حسین مدرسی | mohammad hossein modarressi


سید محمد اکرمی | seyed mohammad akrami


پژمان فرد اصفهانی | pezhman fard esfahani


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-374&slc_lang=en&sid=en
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