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Iranian Biomedical Journal، جلد ۱۷، شماره ۴، صفحات ۲۱۴-۲۲۰
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| عنوان فارسی |
فعالیت سلول های میکروگلیال درمدل تجربی ضایعه نخاعی موش صحرایی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Microglial Activation in Rat Experimental Spinal Cord Injury Model |
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| چکیده انگلیسی مقاله |
Background: The present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (SCI). Methods: A quantitative histological study was performed to determine ED-1 positive cells, glial cell density, and cavitation size in untreated SCI rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. Results: The results of glial cell quantification along the 4900-µm long injured spinal cord showed a significant increase in glial cell density percentage at day 2 as compared to other days. Whereas the highest increase in ED-1 immunoreactive cells (monocyte/phagocyte marker in rats) was observed at day 2 (23.15%) post-injury. Evaluation of cavity percentage showed a significant difference between weeks 3 and 4 post-injury groups. Conclusions: This study provides a new insight into the multiphase immune response to SCI, including cellular inflammation, macrophages/microglia activation, glial cell density, and cavitation. Better understanding of the inflammatory processes associated with acute SCI would permit the development of better therapeutic strategies. |
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| کلیدواژه‌های انگلیسی مقاله |
Spinal cord injuries, Inflammation, Microglia, Macrophages |
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| نویسندگان مقاله |
علیرضا عبدانی پور | alireza abdanipour
تقی طریحی | taki tiraihi
طاهر طاهری | taher taheri
هادی کاظمی | hadi kazemi
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| نشانی اینترنتی |
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-490&slc_lang=en&sid=en |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Related Fields |
| نوع مقاله منتشر شده |
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