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Iranian Biomedical Journal، جلد ۱۷، شماره ۴، صفحات ۲۰۶-۲۱۳
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| عنوان فارسی |
تاثیر تجویز اسید آسکوربیک و سیر بر آپوپتوز ناشی از تماس با سرب در شبکیه چشم نوزادان رت |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Effect of Ascorbic Acid and Garlic Administration on Lead-Induced Apoptosis in Rat Offspring's Eye Retina |
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| چکیده انگلیسی مقاله |
Introduction: Lead toxicity induces retinal cell apoptosis. Vitamin C and garlic may decrease lead-induced apoptosis. This study was undertaken to investigate vitamin C and garlic protective effects on lead-induced apoptosis in eye retina. Methods: Pregnant Wistar rats (n = 72) were divided randomly into 9 groups: (L) treated rats with lead acetate in drinking water and (L+AA) with leaded water and vitamin C intraperitoneally(L+G), the rats received leaded-water and garlic juice via gavage (L+AA+G) treated rats with leaded water, ascorbic acid, and garlic juice, (AA) with ascorbic acid, and (G) with garlic juice (AA+G) treated rats with vitamin C and garlic juice and (Sh) with tap water plus normal hydrogen chloride (HCl) and glucose normal (N). After 21-day lactation, blood lead level (BLL) in rats was measured, and then their offspring and the rat offspring's eyes were removed and processed for using TUNEL method. TUNEL positive cells in the eye retina were counted and all groups were compared. Results: BLL increased in L group compared to the control groups and decreased significantly in L + G, L + AA, and L+ AA + G groups compared to L group (P< 0.05). TUNELL positive cell number in eye retina significantly increased in L group compared to control groups (P< 0.05) and decreased in L+ G, L+ AA, and L+AA + G groups compared to L group (P< 0.05). Conclusion: Garlic juice and ascorbic acid administration during pregnancy and lactation may protect lead-induced apoptosis in rat offspring's eye retina. |
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| کلیدواژه‌های انگلیسی مقاله |
Lead, Garlic, Ascorbic acid, Apoptosis, Retina |
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| نویسندگان مقاله |
الناز خرداد | elnaz khordad
علیرضا فاضل | alireza fazel
علیرضا ابراهیم زاده بیدسکان | alireza ebrahimzadeh bideskan
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| نشانی اینترنتی |
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-487&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Related Fields |
| نوع مقاله منتشر شده |
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