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Iranian Biomedical Journal، جلد ۱۸، شماره ۴، صفحات ۲۰۳-۲۱۱
عنوان فارسی اثر کوآنزیم Q۱۰ بر نسبت TH۱به TH۲ در مدل انسفالومیلیت خود ایمنی تجربی بیماری مالتیپل اسکلروزیز در C۵۷BL/۶
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عنوان انگلیسی Effects of Coenzyme Q10 on the ratio of TH1/TH2 in Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis in C57BL/6
چکیده انگلیسی مقاله Background: Multiple sclerosis (MS) is known as a progressive central nervous system inflammatory disease. Certain factors, such as interleukins, inflammatory cells, and oxidative stress are supposed to involve in MS etiology. Because of the important role of oxidative stress, antioxidant therapy for MS has received more attention. Although coenzyme Q10 (CoQ10) acts as an antioxidant, there is a lack of enough research on its effects on MS. Therefore, the present research was designed. Methods: C57BL/6 female adult mice (n = 30) were used in this study. The animals were randomly divided into trial and control groups. To induce MS, routine procedure for experimental autoimmune encephalomyelitis (EAE) was used, and scoring was performed based on clinical signs. By detecting score one, CoQ10 administration was started (10 mg/kg/three weeks). By using ELISA and real-time PCR, the brain levels of TNF-gamma, IL-10, IL-4, and IL-12 were studied. Statistical tests were used to analyze the data and the P value less than 0.05 was considered to be significant. Results: Clinical symptoms in EAE animals were significantly decreased (P< 0.05) as compared to control ones. In addition, the level of the TNF-gamma was significantly decreased following CoQ10 administration versus IL-10. The ratio of TH1/TH2 interleukins in treated animals was significantly less than that in non-treated animals (P< 0.01). Conclusion: Our findings showed that CoQ10 is capable of suppressing the inflammatory pathway of MS.
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نویسندگان مقاله مریم سلیمانی | maryam soleimani


سید بهنام الدین جامعی | seyed behnamedin jameie


محمود براتی | mahmood barati


مهدی مهدی زاده | mehdi mehdizadeh


مهدیه کرداری | mahdieh erdari


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-523&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Tissue Engineering and Cell Biology
نوع مقاله منتشر شده مقاله کامل
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