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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۱، صفحات ۳۰-۳۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anti-tuberculosis and cytotoxic evaluation of the seaweed Sargassum boveanum
چکیده انگلیسی مقاله Marine seaweeds produce a variety of compounds with different biological activities, including anti-tuberculosis and anticancer effects. The aim of this study was to investigate anti-tuberculosis activity of Sargassum boveanum ( S. boveanum ) and cytotoxicity of different fractions of this seaweed. S. boveanum was collected from Persian Gulf. The plant was extracted by maceration with methanol-ethyl acetate solvent. The extract was evaporated and partitioned by Kupchan method to yield hexane, tricholoroethane, chloroform, and butanol partitions. The anti-tuberculosis activity of the crude extract and toxicity of the fractions were investigated using green fluorescent protein reporter microplate assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay methods, respectively. The cell survivals of HeLa cell were decreased by increasing the concentration of the extracts. The IC 50 values of hexane, tricholoroethane, chloroform, and butanol partitions were 150.3 ± 23.10, 437.0 ± 147.3, 110.4 ± 33.67, and 1025.0 ± 15.20 μg/mL, respectively. The crude extract was not active against tuberculosis. This study reveals that different partitions of S. boveanum have cytotoxic activity against the cancer cell lines.
کلیدواژه‌های انگلیسی مقاله Sargassum,Persian Gulf,Tuberculosis,Cytotoxic
نویسندگان مقاله | Vajihe Akbari
2Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Saeed Zafari
2Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Afsaneh Yegdaneh


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1804
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-628600.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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