این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۳، صفحات ۲۶۲-۲۷۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Synthesis and evaluation of anticonvulsant activity of (Z)-4-(2-oxoindolin-3-ylideneamino)-N-phenylbenzamide derivatives in mice
چکیده انگلیسی مقاله Due to resistance of some epileptic patients to the current medications and the general incidence of severe side effects of these drugs, development and discovery of novel antiepileptic drugs is crucial. Isatin-based derivatives are promising compounds as antiepileptic agents. In this study a new series of isatin-containing derivatives were synthesized via the imine formation between isatin and p -aminobenzoic acid. Subsequently, the obtained acidic compound was utilized to prepare the final amidic derivatives ( 4a-4l ) through the reaction with various aniline derivatives. Then, their anti-seizure activity was investigated using maximal electroshock seizure (MES) as well as pentylenetetrazole (PTZ) models in mice. Neurotoxicity of target compounds was also determined by rotarod test. Tested isatin-based derivatives exhibited a favorable protection in both MES and PTZ procedures with high safety levels in neurotoxicity test. The introduced derivatives have demonstrated remarkable activity in mice and could be suggested as potential anticonvulsant lead compounds. All methoxylated derivatives ( 4j , 4k , 4l ) showed a significant anti-seizure activity in MES model. Compounds 4j (2-OCH 3 ) and 4l (4-OCH 3 ) also demonstrated a potent anti-seizure activity against PTZ. Compound 4k ( m -OCH 3 ) did not induce protection towards PTZ-induced convulsion. 
کلیدواژه‌های انگلیسی مقاله Synthesis,Isatin,Anticonvulsant,PTZ,MES.
نویسندگان مقاله | Marzieh Rahmani Khajouei
2Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah,I.R. Iran. 4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.


| Ahmad Mohammadi-Farani
3Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran. 5Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah,I.R. Iran.


| Aref Moradi
3Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran. 2Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah,I.R. Iran.


| Alireza Aliabadi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1830
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-628437.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات