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Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۱۹، شماره ۲، صفحات ۱۰۹-۰
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عنوان انگلیسی Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess
چکیده انگلیسی مقاله Statement of the Problem: Genetic polymorphisms can alter immunity response against pathogens, which in turn influence individuals’ susceptibility to certain infections. Purpose: Our aim was to determine the association of Arg753Gln (rs5743708) and Arg677Trp (rs12191786) polymorphisms of toll like receptor-2 gene with the two clinical forms of apical periodontitis: acute apical abscess (AAA) and asymptomatic apical periodontitis (AAP). Materials and Method: There were 50 patients with AAA as case group and 50 with AAP as control group. Genotyping was done using Tetra-ARMS (amplification refractory mutation system) PCR. Results: Heterozygous genotype of Arg677Trp polymorphism was associated with risk of AAA (OR=1.9, 95% CI: 0.7-5.5, p = 0.05). Although statistically insignificant, Arg677Trp polymorphism promoted the risk of AAA in dominant model (OR=2.1, 95% CI: 0.7-5.9, p > 0.05). The frequency of mutant allele (T) of Arg677Trp polymorphism was higher in AAA (14%) than AAP (7%) subjects (OR=1.7, 95% CI: 0.6-4.7). For Arg753Gln polymorphism, wild homozygous (GG) represented the dominant genotype in both cases (96%) and controls (100%). Variant allele (A) of Arg753Gln polymorphism was identified in 2% of AAA, while no individual represented with this allele in AAP subjects. Individuals with Arg753Gln; Arg677Trp (GG; TC) combination showed an elevated risk of AAA (OR=1.6, 95% CI: 0.5- 4.2, p > 0.05). Conclusion: Arg677Trp polymorphism of TLR-2 rendered a higher risk for the development of abscesses in apical periodontitis. It is recommended to explore role of this polymorphism in other populations.
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نویسندگان مقاله | Ebrahim Miri-Moghaddam
Oral and Dental Diseases Research Center, Dept. of Endodontics, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.


| Narges Farhad Mollashahi
Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.


| Nava Naghibi
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.


| Yasaman Garme
Faculty of Allied Medical Sciences, Zabol University of Medical Sciences, Zabol, Iran.


| Ali Bazi


نشانی اینترنتی http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1646
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/331/article-331-623443.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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