|
|
Physiology and Pharmacology، جلد ۱۵، شماره ۲، صفحات ۲۴۹-۲۵۹
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Protective role of cyclosporine on the model simulated the rotational nodal arrhythmia (AVNRT) by using extracellular field potential recordings of isolated atrioventricular-node of rabbit |
|
| چکیده انگلیسی مقاله |
Introduction: Recent studies have shown acute cardioprotective effects of cyclosporine. The aim of the present study was to determine the protective role of cyclosporine on the model simulated the rotational nodal arrhythmia (AVNRT) by using extracellular field potential recordings of isolated atrioventricular-node (AV-node) of rabbit. Methods: This study was performed on isolated double-perfused AV-node of male New Zealand rabbits (1.5-2.5 kg) in one group (n=7). Basic and rate-dependent stimulation protocols (recovery, facilitation, fatigue) and arrhythmia threshold (index of refractoriness) and % Gap incidence were measured for assessment of electrophysiological properties of the AV- node. All stimulation protocols were repeated in control step and in the presence of various cumulative concentrations of cyclosporine (0.5 - 10 μm). Results: Cyclosporine prolonged the effective refractory period from 114.3±7.9 to 142±7.3 msec at the concentration of 10 μm. It also prolonged the functional refractory period from 162±3.3 to 178.6±5 msec and increased the time of Wenckebach at the concentrations of 5 - 10 μM. Various concentrations of cyclosporine increased fatigue and reached a significant level at 10 μm. Gap incidence was 82%, 16.6% and 20% in the control and treatments with 0.5 and 10 μm of cyclosporine, respectively. Conclusion: Block of MPTP by cyclosporine caused inhibition of basic and rate-dependent properties of atrioventricular node. Cyclosporine, by raising the threshold of arrhythmia, could be possibly considered as an anti- AVNRT drug. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
وحید خوری | vahid khori
golestan cardiovascular research senter
سپیده شریعت نژاد | sepideh shariatnejad
golestan cardiovascular research senter
علی محمد علیزاده | alimohammad alizadeh
cancer research center, tehran university of medical scinces.tehran,iran.
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
حمیدرضا یزدی | hamidreza yazdi
golestan cardiovascular research senter
مونا پورابوک | mona pourabouk
golestan cardiovascular research senter
فخری بداغ آبادی | fakhri badaghabadi
golestan cardiovascular research senter
حمیدرضا مهیمنی | hamid reza moheimani
شیما چنگیزی | shima changizi
golestan cardiovascular research senter
مریم rajee | maryam rajee
golestan cardiovascular research senter
محسن نایب پور | mohsen nayebpour
tehran university of medical scinces.tehran,iran.
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
|
|
| نشانی اینترنتی |
http://www.phypha.ir/ppj/browse.php?a_code=A-10-245-11&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cardivascular system |
| نوع مقاله منتشر شده |
Original Research |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|