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Basic and Clinical Cancer Research، جلد ۱۰، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Adequacy of the Number of Lymph Nodes Assessed and its Association with Clinico-Pathological information of Gastric Cancer
چکیده انگلیسی مقاله Background: We studied the number of lymph nodes (LN) assessed in gastric cancer, and evaluated the association between different factors and a lower number of LN assessed. Methods: We conducted a retrospective study in three hospitals in Tehran city, I.R. Of Iran. We used patient medical and pathological reports and obtained personal and clinical information. We studied the association of being on the N3 stage with the number of assessed lymph nodes (NALN), gender, tumor size, T stage, hospital, tumor site, histopathological diagnosis, tumor grade and age at diagnosis. In addition, we estimated the association between NALN and different clinical variables. A logistic regression model estimated the crude and adjusted odds ratios (OR) and corresponding 95% confidence intervals (95% CI). Results: The average number of NALN was 10.48 (±6.9). We found that the probability of being diagnosed as stage N3 was significantly lower in patients who had less than 15 LN assessed compared to those who had more than 15 LN assessed in their pathology reports (OR=0.2; 95% CI 0.1-0.4). The hospital, tumor sizes were significantly associated with NALN. Conclusion: Lower NALN led to stage migration and underestimation of the real tumor stage in GC patients. The LN assessments were lower than recommended by the American Joint Cancer Clinician Association in all the three hospitals included in this study. Developing national guidelines, training surgeons and pathologists, conducting regular monitoring and evaluation of the data is necessary to increase NALN and thus improve the staging of GC patients.
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نویسندگان مقاله | Mojtaba Vand Rajabpour
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran


| Elena Ghotbi
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran


| Sepideh Azizi
Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Tehran, I.R. of Iran


| Bahram Salmanian
Clinical Cancer Research Center, Milad General Hospital, Tehran, I.R. of Iran


| Hossein Yahyazadeh
Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Tehran, I.R. of Iran


| Hossein Khedmat
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran


| Afshin Abdirad
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran


| Iraj Harirchi
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran


| Kazem Zendehdel


نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/263
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نوع مقاله منتشر شده Original Articles
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