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Physiology and Pharmacology، جلد ۱۹، شماره ۱، صفحات ۲۲-۳۰
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عنوان انگلیسی Effects of bilateral lesion of the locus coeruleus on the sleep-wake cycle in the rat
چکیده انگلیسی مقاله Introduction: Noradrenergic cells in LC participate in the process of cortical activation and behavioral arousal. The evidence suggests that locus ceoruleus (LC) plays an important role in the sleep-wake cycle. The aim of this study was stereological estimation of cavity caused by lesion and assessment of sleep stages after bilateral lesion of the LC. Materials and Methods: Male Wistar rats weighting 250-275 gr were divided into four groups (control: n=6, sham: n=6, lesion1: n=6 and lesion2: n=6). 6 hydroxydopamine (6 OHDA) (2μg/0.5μl and 4μg/1μl) was sterotaxically injected bilaterally into LC to produced lesion. For sleep recording 3 EEG and 2 EMG electrodes were implanted respectively in the skull and dorsal neck muscle. Recordings were taken before and 7, 21 and 42 days after lesion. After 7 weeks, Rats first were anesthetized and then their brains were removed and cut in 7 μm serial sections and stained with cresyl violet. The volume of LC and the lesion induced cavity were evaluated through the stereological technique. Results: Lesion - induced cavity volume (0.5 μl) was restricted to LC, whereas Another group (1 μl), total LC and structures adjacent to the LC were also damaged. A significant decrease was seen in non-rapid eye movement (NREM) and paradoxical sleep (PS) stages and a significant increase was seen in duration of wake and paradoxical sleep without atonia (PS-A) in lesion group in comparison with control and sham groups. Conclusion: The results of this study demonstrate 2μg/0.5μl 6-OHDA is suitable dose for LC lesion and bilateral lesion of LC causing disrupt wake, NREM ,PS and also produce the PS-A.
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نویسندگان مقاله وحید پیرحاجاتی مهابادی | vahid pirhajati mahabadi
anatomical sciences department, faculty of medicine, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

منصوره موحدین | mansoureh movahedin
anatomical sciences department, faculty of medicine, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

زهره مظاهری | zohreh mazaheri
anatomical sciences department, faculty of medicine, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

سعید سمنانیان | saeed semnanian
physiology department, faculty of medicine, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

جواد میرنجفی زاده | javad mirnajafi zadeh
physiology department, faculty of medicine, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

مهرداد فیضی | mehrdad faizi
pharmacology and toxicology department, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-820-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neurodegeneretive diseases
نوع مقاله منتشر شده Original Research
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