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Physiology and Pharmacology، جلد ۲۰، شماره ۳، صفحات ۱۸۹-۱۹۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Anti-nociceptive effect of Tanacetum Fisherae on formalin-induced inflammatory pain in rats |
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| چکیده انگلیسی مقاله |
Introduction: The management of pain and inflammation related problem is a real challenge that people face daily. Although several drugs are available for these conditions, medicinal plants are believed to be an important source of new chemical substances with potential therapeutic effects. The objective of current study was to investigate the anti-nociceptive effect of Tanacetum Fisherae which has been traditionally used for treatment of pain. Methods: In this experimental study, formalin test was performed with drug (Tanacetum Fisherae) or DMSO pretreatment 30 min prior to formalin injection in 40 male Wistar rats. Fifty microliters of 2.5% formalin was injected into the plantar surface of the right hind paw. Immediately after injection, licking and flinching number and paw-shaking responses were observed at 5-min intervals for 1 h. Animals were divided into five experimental groups. There were 8 animals in each group. Each group received vehicle (7% DMSO) or Tanacetum Fisherae essential oil (25, 50 or 100 μg) or morphine (5 mg/kg). Two-way and one-way ANOVA were used for data analysis. Differences were considered significant at the level of P< 0.05 (with 95% confidence interval). Results: Results showed that Tanacetum Fisherae essential oil dose dependently reduced licking and flinching number and also pain score in the late (15-35 min) and recovery phase (35-60 min) of formalin test (p< 0.05, p< 0.01, and p< 0.001). It had no anti-nociceptive effect (p>0.05) in early (0-5 min) phase and interphase (5-15 min). Conclusion: Results demonstrate the effectiveness of Tanacetum Fisherae to mitigate the inflammatory pain. |
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| کلیدواژه‌های انگلیسی مقاله |
Pain, Formalin test, Tanacetum Fisherae |
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| نویسندگان مقاله |
محسن فتحی | mohsen fathi
department of physiology, medical school, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
نرگس حسین مردی | narges hosseinmardi
department of physiology, medical school, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
کامبیز رهام پور | kambiz rohampour
department of physiology, guilan university of medical science, rasht, iran
سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)
مهیار جان احمدی | mahyar janahmadi
department of physiology, medical school, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
علی سنبلی | ali sonboli
department of physiology, guilan university of medical science, rasht, iran
سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)
جلال زرین قلم | jalal zaringhalam
department of physiology, medical school, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
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| نشانی اینترنتی |
http://www.phypha.ir/ppj/browse.php?a_code=A-10-677-2&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Pain and addiction |
| نوع مقاله منتشر شده |
Original Research |
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