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Research in Pharmaceutical Sciences، جلد ۱۱، شماره ۳، صفحات ۲۵۹-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Frequency distribution of polymorphisms of CYP2C19, CYP2C9, VKORC1 and SLCO1B1 genes in the Yakut population |
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| چکیده انگلیسی مقاله |
Allele frequencies of single nucleotide polymorphisms (SNPs) are variable among different populations; therefore the study of SNPs in ethnic groups is important for establishing the clinical significance of the screening of these polymorphisms. The main goal of the research is to study the polymorphisms of CYP2C9 , CYP2C19 , VKORC1 , and SLCO1B1 in Yakuts. Genomic DNA from 229 Yakut subjects were analyzed by real-time polymerase chain reaction (PCR) ( SLCO1B1 +521T > C, VKORC1 -1639G>A , CYP2C19 +681G>A, +636G>A , CYP2C9 +430С>T, +1075A>C). Genotype frequencies of polymorphisms in the population of the Yakuts were more characteristic of the Asian population. The results have been included in the software application “Lekgen” that we developed for the interpretation of pharmacogenetic testing. The data of our study obtained on frequency carriers of polymorphisms of genes SLCO1B1 , СYP2C19 , CYP2C9 , VKORC1 among the Yakuts may be useful in developing recommendations for a personalized therapy. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
filipp filippovich vasilyev | filipp filippovich vasilyev
دیانا aleksandrovna danilova | diana aleksandrovna danilova
ولادیمیر sergeevich kaimonov | vladimir sergeevich kaimonov
yana valerievna chertovskih | yana valerievna chertovskih
nadezda romanovna maksimova | nadezda romanovna maksimova
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| نشانی اینترنتی |
http://rps.mui.ac.ir/index.php/jrps/article/view/1699 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Short Communication |
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