این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Basic and Clinical Cancer Research، جلد ۹، شماره ۲، صفحات ۳۸-۴۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Endoplasmic Reticulum Stress as a Therapeutic Target in Cancer: A mini review
چکیده انگلیسی مقاله Perturbation of endoplasmic reticulum (ER) homeostasis leads to a stress condition described as “ER stress” which can induce the well-regulated program termed as unfolded protein response (UPR). The principal purpose of UPR is to reestablish the ER homeostasis. Some of the physiological and pathological situations that disrupt the homeostasis including hypoxia, glucose limitations, nutrient deprivation, low pH, genomic instability, and some cytotoxic compounds are frequently observed during the core formation and progression of tumors. These stressful microenvironments around the tumors affect the innate and adaptive immune responses. In Addition, different immunoregulatory myeloid populations, like dendritic cells, myeloid-derived suppressor cells (MDSCs) and macrophages, accumulate in the tumor milieu and are barrier to cancer immunotherapy. In these stressful situations, ER stress is usually induced to activate the UPR. Although the UPR mechanism is primarily a pro-survival process, preserved and/or prolonged excessive stress may induce cell apoptosis. Cancer and sustained ER stress may have modifications in ER stress mediated cell apoptosis and facilitate chronic inflammation and immune suppression within tumors. In this mini review, at first, we discuss the role of UPR and its mediators in cancerous cells fate and their potential opportunities in cancer therapy. 
کلیدواژه‌های انگلیسی مقاله ER stress response,unfolded protein response,cancer therapy
نویسندگان مقاله مروه رحمتی | marveh rahmati
cancer biology research center, cancer institute of iran, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سعید امان پور | saeid amanpour
cancer biology research center, cancer institute of iran, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

امیرحسین kharman بیز | amirhossein kharman biz
department of molecular medicine, institute of medical biotechnology, national institute for genetic engineering and biotechnology, tehran, iran


محمد امین موسوی | mohammad amin moosavi


نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/252
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/151/article-151-568685.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Mini-Reviews
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات