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Iranian Journal of Kidney Diseases، جلد ۳، شماره ۴، صفحات ۲۰۳-۰
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عنوان انگلیسی Arterial Atherosclerosis in Patients With Chronic Kidney Disease and Its Relationship With Serum and Tissue Endothelin-1
چکیده انگلیسی مقاله Instruction. We investigated the correlation between atherosclerosis and tissue and serum levels of endothelin-1 in patients with chronic kidney disease (CKD). Materials and Methods. Arterial samples were obtained from 35 patients with CKD during arteriovenous fistula placement. Thirty-one patients with cardiovascular disease who underwent coronary artery bypass graft (CABG) were selected as the atherosclerotic group, and a piece of their aorta punched during CABG was obtained. Also, a small piece of the renal artery was dissected during donation in 24 kidney donors (control group). Tissue endothelin-1 level was measured and atherosclerosis grading was determined by pathologic examination. Serum levels of endothelin-1 were also measured in the three groups. Results. The mean tissue endothelin-1 levels were 10.73±7.57 pg/mL, 12.16 ± 3.95 pg/mL, and 0.93 ± 1.06 pg/mL in the patients with CKD, those with CABG, and donors, respectively (P Conclusions. Tissue endothelin-1 concentration is more important than serum endothelin-1 or lipids levels in prediction of atherosclerosis. Thus, blockade of tissue endothelin-1 receptors with its antagonists may prevent atherosclerosis progression.
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نویسندگان مقاله حمید نوشاد | hamid noshad


حسن ارگانی | hassan argani


نریمان نظامی | nariman nezami


مرتضی قوجازاده | morteza ghojazadeh


افشار زمردی | afshar zomorrodi


ابوالفضل بهلولی | abolfazl bohlouli


محمدرضا بنیادی | mohammad reza bonyadi


اشرف فخرجو | ashraf fakhrjou


امیر قربانی حق جو | amir ghorbanihaghjo


اباسط قره داغی | abasat gharedaghi


حسن جوادزادگان | hasan javadzadegan


شهرام صدرالدینی | shahram sadreddini


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/107
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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