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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۱، صفحات ۶۵-۷۲
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Magnesium sulfate protects the heart against carbon monoxide-induced cardiotoxicity in rats
چکیده انگلیسی مقاله Carbon monoxide (CO), a toxic gas produced via incomplete fossil fuel combustion, has several poisonous effects in the heart including induction of necrosis, apoptosis, and electrocardiogram (ECG) changes. Magnesium sulfate (MS) is a drug with cardioprotective effects especially when used after ischemia/reperfusion. In the current study, we aimed to evaluate MS cardioprotective effects following CO poisoning. Animals were exposed to CO 3000 ppm for 1 h and immediately after the exposure period and on the next 4 days (a total of 5 consecutive doses given on a daily basis), MS (75, 150 and 300 mg/kg) was injected intraperitoneally (i.p.) and ECG was recorded focusing on ST-segment, T-wave, and Q-pathologic wave changes. On day 5, animals were sacrificed and their heart was excised for determination of BAX, BCL2 and Akt expression level using western blot analysis and necrosis investigations. The results showed that MS significantly decreased necrosis and BAX/BCL2 ratio ( P < 0.001) while pro-survival protein Akt was significantly increased ( P < 0.001). Moreover, CO-induced ST-segment depression, T-wave inversion, and atrioventricular block (AV-block) were decreased following treatment with MS. In conclusion, our results showed that MS could decrease cardiac deleterious effects of CO poisoning including necrosis and apoptosis while increased the expression of Akt, as a cell survival protein.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله کاوه تبریزیان | kaveh tabrizian
1department of pharmacodynamics and toxicology, school of pharmacy, zabol university of medical sciences, zabol, i.r. iran. 2students research committee, school of pharmacy, zabol university of medical sciences, zabol, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)

حمیده خدایاری | hamideh khodayari
3clinical research unit, faculty of medicine, mashhad university of medical sciences, mashhad, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

رامین رضایی | ramin rezaee
4department of pathology, amiralmomenin hospital, zabol university of medical sciences, zabol, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)

حسینعلی جهانتیغ | hosseinali jahantigh4
5health department, faculty of health, zabol university of medical sciences, zabol, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)

غلامرضا باقری | gholamreza bagheri
6department of cardiology, university hospital of larissa, larissa, greece.


konstantinos tsarouhas | konstantinos tsarouhas
1department of pharmacodynamics and toxicology, school of pharmacy, zabol university of medical sciences, zabol, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)

محمود هاشمزایی | mahmoud hashemzaei


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1809
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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