این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۱، صفحات ۱۹-۲۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Protective effect of metformin on D-galactose-induced aging model in mice
چکیده انگلیسی مقاله Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), was administrated daily in D-gal-received (500 mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Results: Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. Conclusion: Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors.
کلیدواژه‌های انگلیسی مقاله Aging, D-galactose, Metformin, Mouse, Oxidative stress
نویسندگان مقاله ایمان فاطمی | iman fatemi
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran|department of physiology and pharmacology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

امین خالویی | amin khaluoi
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

آیت کاییدی | ayat kaeidi
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran|department of physiology and pharmacology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

علی شمسی زاده | ali shamsizadeh
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran|department of physiology and pharmacology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

سارا حیدری | sara heydari
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

محمد الله توکلی | mohammad allahtavakoli
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran|department of physiology and pharmacology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_9918.html
فایل مقاله دریافت فایل مقاله
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات