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Journal of Kerman University of Medical Sciences، جلد ۲۴، شماره ۴، صفحات ۲۸۹-۲۹۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Neuroprotective effects of voluntary wheel running and eriobotrya japonica flower extract on Parkinsonian rats |
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| چکیده انگلیسی مقاله |
Backgrounds: The loss of dopamine-secreting cells and the decrease in the status of antioxidant is associated with incidents of Parkinson's disease. The purpose of the present study was to determine the protective effect of a 12- weeks voluntary wheel running (VWR) along with the injection of eriobotrya japonica flower extract (EJFE, 200 mg/kg body weight, 3 days a week) on cerebral dopamine neurotrophic factor (CDNF), superoxide dismutase (SOD), and malondialdehyde (MDA) in the cerebral cortex of a rat model of Parkinson's disease (PD). Method: To do so, the rats were trained for 12 weeks with and without EJFE prior to the induction of Parkinson. In order to obtain the Parkinsonian model, 6-hydroxydopamine (6-OHDA) (5 µL) was injected intracerebrally. Data were statistically analyzed by one-way analysis of variance followed by LSD post-hoc test (P < 0.05). Results: 6-OHDA injection significantly decreased the CDNF contents, and SOD activity while it increased MDA levels in cerebral cortex of the Parkinsonian control group. The pre-training of PD rats with and without EJFE increased the CDNF content and SOD activity and also decreased MDA levels. Conclusion: Preconditioning by VWR and EJFE may be effective in reducing the consequences of toxins resulted in Parkinson's disease. |
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| نویسندگان مقاله |
حسین شیروانی |
assistant professor, exercise physiology research center, life style institute, baqiyatallah university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)
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| نشانی اینترنتی |
http://jkmu.kmu.ac.ir/article_53929_466aaebb52873ff43677a506696d49f6.pdf |
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| زبان مقاله منتشر شده |
en |
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