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Iranian Journal of Microbiology، جلد ۹، شماره ۴، صفحات ۲۰۰-۲۰۷
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عنوان انگلیسی Phenotypic and genotypic features of first biofilm forming nasopharyngeal colonized Streptococcus pneumoniae isolates
چکیده انگلیسی مقاله Abstract Background and Objectives: Designing control and therapeutic policies for antibiotic resistant Streptococcus pneumoniae , which is an important causative agent of several invasive and noninvasive infectious diseases and its carriage rates, has been described as the main target in World Health Organization (WHO). The present study was conducted to determine antibiotic resistance pattern, evaluate biofilm forming ability in S. pneumoniae isolates, and find the genetic relationship between cultured strains. Materials and Methods: Following the isolation and identification of S. pneumoniae strains from nasopharyngeal swabs, the ability of biofilm formation and susceptibility pattern of the isolates were screened using semi-quantitative microplate and disk diffusion procedures. Subsequently, Pulse field gel electrophoresis (PFGE) method was used to determine the clonal diversity of isolates. Results : The pneumococcal colonization rate in this study was found to be 24%. A large number of our isolates had strong biofilm forming ability. However, there was variation in antibiotic resistance patterns of isolates in children who lived in nursery houses. The genetic similarity among the isolates in PFGE varied from 26.5% to 100% in our isolates. This was the first report of biofilm formation of nasopharyngeal colonized S. pneumoniae in Iran. Genetic variations were also noticeable, when the isolates were fingerprinted by PFGE. Conclusion : The findings of this study revealed the need for thoughtful use of antimicrobial agents, continued monitoring of pneumococcal resistance patterns, and prevention of the spread of multi-drug resistant clones.
کلیدواژه‌های انگلیسی مقاله Biofilm, S. pneumoniae, PFGE, Clonal diversity
نویسندگان مقاله سید فضل اله موسوی | seyed fazlollah mousavi
department of bacteriology amp; microbiology research center, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

بهمن میرزایی | bahman mirzaei
department of bacteriology amp; microbiology research center, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

بهاره شقاقی | bahareh shaghaghi
department of bacteriology amp; microbiology research center, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

پانته آ جلالی | pantea jalali
department of bacteriology amp; microbiology research center, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

طاهره ستایش | tahereh setayesh
department of bacteriology amp; microbiology research center, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

سید حمید موسوی | seyed hamid moosavi


نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/1179
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