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Iranian Biomedical Journal، جلد ۲۲، شماره ۱، صفحات ۱۵-۲۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Low Level of Autophagy-Related Gene 10 (ATG10) Expression in the 6-Hydroxydopamine Rat Model of Parkinson's Disease |
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| چکیده انگلیسی مقاله |
Background: Autophagy is a mechanism disassembling the damaged organelles from the cell. This study attempted to examine the expression of several autophagy-related genes in Parkinson's disease (PD) rat model. Methods: The male Wistar rats were divided into three groups as control, sham, and lesion. In the latter group, the PD rat model was induced by the injection of 6-hydroxydopamine in the striatum.The behavioral test was conducted one (baseline) and four weeks after the surgery through apomorphine hydrochloride. Then the RT-PCR technique was employed to evaluate the expressions of p62/SQSTM, autophagy-related genes (ATG)5, ATG12, ATG16L1, ATG10, GAPDH, and LC3. Results: By injecting apomorphine, the striatal lesion group showed a significant contralateral rotation at fourth week as compared to the baseline. The examination of p62, ATG5, ATG12, ATG16L1, and LC3 expressions using RT-PCR revealed that p62, ATG5, ATG12, LC3, and ATG16L1 were expressed in the substantia nigra of PD rat model, while ATG10 was not expressed. Conclusion: ATG10 expression is necessary for the initiation of autophagy. Thus, these results show that autophagy deregulation occurs in the initiation stages of the process in the rat model of PD. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
مرضیه شمس نورایی | marzieh shams nooraei
cellular and molecular research center, qazvin university of medical science, qazvin, iran
علی نوری زاده | ali noori zadeh
department of clinical biochemistry, faculty of medicine, ilam university of medical sciences, ilam,iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)
شهرام دارابی | shahram darabi
cellular and molecular research center, qazvin university of medical science, qazvin, iran
فرزاد رجایی | farzad rajaei
cellular and molecular research center, qazvin university of medical science, qazvin, iran
زهره گل محمدی | zohreh golmohammadi
cellular and molecular research center, qazvin university of medical science, qazvin, iran
حجت اله عباس زاده | hojjat allah abbaszadeh
hearing disorder research center, shahid beheshti university of medical science,tehran, iran
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)
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| نشانی اینترنتی |
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-678&slc_lang=en&sid=en |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Related Fields |
| نوع مقاله منتشر شده |
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