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Iranian Journal of Otorhinolaryngology، جلد ۲۹، شماره ۶، صفحات ۳۶۵-۳۶۸
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عنوان انگلیسی Xanthoma Disseminatum Presenting with Hoarseness
چکیده انگلیسی مقاله Introduction: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder with unknown etio-pathology. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs with a predilection for flexures and the face.  Case Report: We report a patient who presented with disseminated xanthomatous papules and nodules involving the face, neck, trunk, axilla, groin, and oral cavity, along with hoarseness of voice. Video laryngoscopy revealed multiple yellowish nodules over the base of the tongue, vallecula, laryngeal surface of the epiglottis, ary-epiglottic folds, interarytenoid region, and subglottic region. Histopathology was suggestive of  xanthoma disseminatum and the patient was treated with tablet acitretin 25mg daily for three months without any response. Following this, the patient was prescribed tablet thalidomide 100 mg daily without any significant improvement at the end of two months.  Conclusion: Xanthoma disseminatum is a very rare form of non-Langerhans cell histiocytosis that classically presents with cutaneous xanthomas, mucosal xanthomas, and diabetes insipidus. Hoarseness of voice due to lesions involving the larynx is a rare symptom. Because the disease has punctated, numerous relapses and causes morbidity to the patient, its multisystem manifestations have to be known. Therefore, xanthoma disseminatum has to be kept in mind as a differential  diagnosis for hoarseness of voice.    
کلیدواژه‌های انگلیسی مقاله Hoarseness, Vocal cord, Xanthoma
نویسندگان مقاله biswanath behera | biswanath behera
department of dermatology, venereology and leprology, jipmer, puducherry, india.


munisamy malathi | munisamy malathi
department of dermatology, venereology and leprology, jipmer, puducherry, india.


devinder mohan thappa | devinder mohan thappa
department of dermatology, venereology and leprology, jipmer, puducherry, india.


hemanth vamanshankar | hemanth vamanshankar
department of ent, jipmer, puducherry, india.


pradipta کومار parida | pradipta kumar parida
department of ent, jipmer, puducherry, india.


دباسیس gochhait | debasis gochhait
department of pathology, jipmer, puducherry, india.
نشانی اینترنتی http://ijorl.mums.ac.ir/article_9581.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Case Report
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