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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۶، صفحات ۶۷۶-۶۸۲
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عنوان انگلیسی Allicin attenuates tunicamycin-induced cognitive deficits in rats via its synaptic plasticity regulatory activity
چکیده انگلیسی مقاله Objective(s): To illuminate the functional effects of allicin on rats with cognitive deficits induced by tunicamycin (TM) and the molecular mechanism of this process. Materials and Methods: 200–250 g male SD rats were divided into three groups at random: control group (n=12), TM group (5 μl, 50 μM, i.c.v, n=12), and allicin treatment group (180 mg/kg/d with chow diet, n=12). After 16 weeks of allicin treatment, the learning ability and memory were tested using novel object recognition (NOR) testing on rats with 72 hr TM treatment (5 μl, 50 μM, i.c.v); meanwhile, the variation of field excitatory postsynaptic potential (fEPSP) in the Schaffer Collateral (SC)-CA1 synapse was detected by extracellular electrophysiological recordings and the morphology of dendritic spine was observed by Golgi staining as well as detecting several synaptic plasticity-related proteins by Western blot. Results: The density of dendritic spine was increased significantly in allicin-treated groups and the correspondence slope of fEPSP in TM-induced cognitive deficits group was enhanced and expression of synaptophysin and glutamate receptor-1(GluR1) in hippocampal neurons was up-regulated. Conclusion: The results indicate that allicin plays an important role in synaptic plasticity regulation. These finding showed that allicin could be used as a pharmacologic treatment in TM-induced cognitive deficits.
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نویسندگان مقاله qiong xiang | qiong xiang
institute of medicine, medical research center, jishou university, hunan, china


xian هیو li | xian hui li
institute of medicine, medical research center, jishou university, hunan, china


bo یانگ | bo yang
jishou university first affiliated hospital, jishou university, hunan, china


xin xing fang | xin xing fang
institute of medicine, medical research center, jishou university, hunan, china


جینگ جیا | jing jia
institute of medicine, medical research center, jishou university, hunan, china


jie ren | jie ren
institute of medicine, medical research center, jishou university, hunan, china


yu chun دانک | yu chun dong
institute of medicine, medical research center, jishou university, hunan, china


چنگ ou یانگ | cheng ou yang
institute of medicine, medical research center, jishou university, hunan, china


guang چنگ ونگ | guang cheng wang
college of chemistry and chemical engineering, jishou university, hunan, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_8837.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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