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Journal of Kerman University of Medical Sciences، جلد ۲۳، شماره ۱، صفحات ۱۲-۲۰
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عنوان انگلیسی The Effect of Oral Selenium on Radiotherapy Induced Mucositis in Patients with Head and Neck Cancer: a Pilot double-blind study
چکیده انگلیسی مقاله Background & Aims: The purpose of this study was to evaluate the efficacy of oral selenium in alleviation of oral mucositis induced by radiotherapy in head and neck cancer patients. Methods: In a randomized double blind pilot study, 35 patients under radiotherapy, due to primary tumors localized in the head or neck, who had at least two oral sites were studied. They were randomly divided into the treatment group (oral selenium 400 mcg/day) and placebo group. The intervention started one day before radiotherapy and continued for three weeks after the end of the treatment. Mucosal evaluation was done every week during the course of radiotherapy. NCI-CTC (version 2) grading system and Epstein scoring system were used for the assessment of mucositis. Oral cavity was divided into the 14 anatomical sites and relevant sites were examined weekly. Based on the degree of mucositis, each site was scored using 4-point scale and then mean mucositis score was calculated. Results: In whole,35 patients were enrolled into the study. Mean score of mucosistis in selenium group was less than placebo group in the first, second and third weeks (respectively, 0.51 ± 0.28, 1.35 ±0.55 and 1.75 ±0.34 in the selenium group and 1.21 ±0.81, 1.79 ± 0.43, 2.08 ± 0.46 in the placebo group). Repeated measure ANOVA analysis revealed significant increase in mucositis (p=0.019) in the placebo group compared to the selenium group. Conclusion Results of this study support the hypothesis that oral selenium can be considered as an effective and well-tolerated medication for the prevention of radiation induced oral mucositis.
کلیدواژه‌های انگلیسی مقاله Selenium, radiotherapy, Mucositis, Oral cavity
نویسندگان مقاله احمد عامری |
associate professor, department of radiotherapy, imam hossein hospital, shahid beheshti university of medical scinces, tehran, iran
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

محمد عباسی نظری |
associate professor, department of clinical pharmacy, school of pharmacy, shahid beheshti university of medical scinces, tehran, iran
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

عاطفه فاضلی |
pharmacist, department of clinical pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

فرهاد صراف زاده |
assistant professor, department of infectious diseases, afzalipour hospital, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

آرش محبوبی |
assistant professor, department of pharmaceutics amp; pharmaceutical nanothechnology, school of pharmacy, shahid beheshti university of medical scinces, tehran, iran
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://jkmu.kmu.ac.ir/article_51028_e1dffad308e8ffa0605fc29936b8b133.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-475699.pdf
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