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Iranian Journal of Microbiology، جلد ۵، شماره ۱، صفحات ۲۸-۳۵
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عنوان انگلیسی Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA.
چکیده انگلیسی مقاله Background and Objectives: Alterations in CXCL10 (a Th1 chemokine) expression have been associated with various diseases. The aim of this study was to evaluate the serum CXCL10 levels in H. pylori -infected patients with peptic ulcer (PU), H. pylori -infected asymptomatic (AS) subjects and healthy H. pylori -negative subjects, and also to determine its association with bacterial virulence factor cytotoxin - associated gene A (CagA). Materials and Methods: Serum samples from 90 H. pylori infected patients with PU (70 were anti- CagA +, 20 were anti- CagA -), 65 AS carriers (40 were anti- CagA +, 25 were anti- CagA -) and 30 healthy H. pylori -negative subjects (as a control group) were tested for concentrations of CXCL10 by using the ELISA method. Results: The mean serum levels of CXCL10 in PU patients (96.64 ± 20.85 pg/mL) were significantly lower than those observed in AS subjects (162.16 ± 53.31 pg/mL, P < 0.01) and the control group (193.93 ± 42.14 pg/mL, P < 0.02). In the PU group, the serum levels of CXCL10 in anti- CagA + subjects was significantly higher in comparison to anti- CagA - patients (P < 0.04). Conclusion: These results showed that the mean concentrations of CXCL10 in H. pylori -infected-PU patients was lower than AS carriers and control group. In the PU group, the serum levels of CXCL10 were associated with bacterial factor CagA .
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نویسندگان مقاله عبدالله جعفرزاده | abdollah jafarzadeh
department of microbiology and immunology, medical school, rafsanjan university of medical sciences, rafsanjan, iran and immunology research center, rafsanjan university of medical sciences, rafsanjan, iran and molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

مریم نعمتی | maryam nemati
department of microbiology and immunology, medical school, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

محمد تقی رضایتی | mohammad taghi rezayati
department of microbiology and immunology, medical school, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

حسین خرم دل | hossain khoramdel
immunology research center, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

منصوره نبی زاده | mansooreh nabizadeh
department of microbiology and immunology, medical school, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

غلامحسین حسن شاهی | gholamhossain hassanshahi
immunology research center, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

حمید عبداللهی | hamid abdollahi
department of microbiology and immunology, medical school, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/640
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