این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Microbiology، جلد ۷، شماره ۲، صفحات ۱۰۹-۱۱۷
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عنوان انگلیسی Molecular epidemiology of hepatitis C virus and its relation with persistence or clearance of infection in Hamadan, West-Iran
چکیده انگلیسی مقاله Background and Objectives : Hepatitis C Virus genotyping appears to be vital for predicting the response to antiviral therapy. The present study aimed to analyze the HCV genotypes in relation to persistence or clearance of the virus in residents of Hamadan Province, West-Iran. Material and Methods : A total of 1159 recorded questionnaires of HCV infected people were evaluated in this prospective study. Several parameters including HCV genotypes, anti-HCV antibodies, viral load, drug treatment, response to therapy and amount of ALT and AST were analyzed. Results : HCV genotyping in 637 samples revealed a predominance of type 1a (52.1%) followed by 3a (42.4%), type 1b (2.7%) and type 2 (0.2%) respectively. Mixed genotypes (3a-1a) were detected in 0.9%, and 1.7% had untypable genotype. High frequency of genotypes 1a and 3a were observed in drug-resistant (group-a) and drug-sensitive (group-b) patients respectively (P< 0.0001). Additionally, duration of drug treatment was significantly higher in group-a than group-b (P< 0.0001). During follow-up period, 92 cases showed spontaneous clearance of HCV infection and more importantly 86 of 92 cases were positive for anti-HCV antibodies compared with 59 of 455 antibody positive cases with treatment-induced clearance of HCV infection (P< 0.0001). Conclusion : HCV genotyping and also antibody screening could be useful for proper therapeutic intervention in HCV infected subjects.
کلیدواژه‌های انگلیسی مقاله Epidemiology,Genotype,HCV,Antibody
نویسندگان مقاله قاسم سلگی | ghasem solgi
immunology department, medical school, hamadan university of medical sciences, hamadan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

مسعود صبوری قناد | masoud sabouri ghannad
department of microbiology, medical school, hamadan university of medical sciences, hamadan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

علیرضا خلیلیان | alireza khalilian
department of gastroenterology, medical school, hamadan university of medical sciences, hamadan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

امیر مجلسی | amir majlesi
department of gastroenterology, medical school, hamadan university of medical sciences, hamadan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

مهرداد حاجیلو | mehrdad hajiloo
immunology department, medical school, hamadan university of medical sciences, hamadan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/151
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