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Iranian Journal of Microbiology، جلد ۸، شماره ۲، صفحات ۸۵-۹۲
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عنوان انگلیسی Modulation of antibiotic resistance in Pseudomonas aeruginosa by ZnO nanoparticles
چکیده انگلیسی مقاله Background and Objectives: Bacterial resistance to conventional antibiotics has become a widespread public health prob- lem. The aim of this study was to investigate the influence of zinc oxide nanoparticles (ZnO NPs) on the antibacterial activity of several conventional antibiotics against Pseudomonas aeruginosa. Materials and Methods: ZnO NPs were prepared by solvothermal method and dispersed in glycerol with the help of ammo- nium citrate as a dispersant. The antibacterial effects of the resulting ZnO nanofluid, ceftazidime, tobramycin, and ciproflox- acin were investigated against two P. aeruginosa strains, including one clinical isolate and P. aeruginosa ATCC 9027 using microdilution method. For the evaluation of the combined effect of ZnO nanofluid and antibiotics, the fractional inhibitory concentration indices were calculated and isobolograms were plotted. Results: Clinical strain in comparison to standard strain of P. aeruginosa showed more resistance to ZnO nanofluid and the antibiotics. ZnO nanofluid acted synergistically with ceftazidime and tobramycin against both strains. Combination of ZnO nanofluid and ciprofloxacin displayed synergistic and partial synergistic activity against clinical and standard strains of P. aeruginosa, respectively. Conclusion: The results suggest that bacterial resistance to antimicrobials could be reduced by the synergistic action of ZnO NPs.
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نویسندگان مقاله الناز bayroodi | elnaz bayroodi
department of chemistry, faculty of sciences, ferdowsi university of mashhad, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

راضیه جلال | razieh jalal
department of chemistry, faculty of sciences, ferdowsi university of mashhad, mashhad, iran and cell and molecular biotechnology research group, institute of biotechnology, ferdowsi university of mashhad, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/859
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