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Iranian Journal of Microbiology، جلد ۸، شماره ۳، صفحات ۲۰۳-۲۰۹
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عنوان انگلیسی Carriage rates of Neisseria meningitides serogroups: determination among freshmen conscripts before vaccination
چکیده انگلیسی مقاله Background and Objectives: Neisseria meningitidis is transmitted from person-to-person. Thus, close contact with a healthy carrier can facilitate the spread of the bacteria and lead to life-threatening meningococcal disease. The aim of this study was to identify oropharyngeal carriers of N. meningitidis in volunteers preparing for military service before vaccination. Materials and Methods: In a cross-sectional study, 226 volunteers entering military service were referred to the Shemiranat Health Center for meningococcal vaccination and assayed. Before vaccination, the participants underwent sampling of the throat using separate swabs. Thayer-Martin Agar medium and microbiological standard methods were used for culture and isolation of the organisms. The bacterial isolates were subjected to DNA extraction and polymerase chain reaction. The obtained data were descriptively analyzed. Results: Out of the 226 (100%) young volunteers, only 18 (8%) yielded Gram-negative diplococci. The results showed the presence of N. meningitidis (carriage rate: 8%) in their oropharyngeal regions. The isolated serogroups were C, A, Y, W-135, and X with frequencies of 50, 22.2, 16.6, 5.5, and 5.5, respectively. Discussion: This study showed that the carriage rate in young volunteers for military service is around 8% before vaccination. Although the rates for serogroups A and C were dominant, the existence of serogroups Y and W indicate the necessary revision of the A/C vaccine. More research is needed to determine serogroup diversity and decrease the risk of meningococcal disease in individual groups.
کلیدواژه‌های انگلیسی مقاله Conscripts,Healthy carrier,PCR,Neisseria meningitidis
نویسندگان مقاله رمضانعلی عطایی | ramazanali ataei
department of medical microbiology, faculty of medicine, baqiyatallah university of medical sciences,tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

علی محرابی توانا | ali mehrabi tavana
health management research center and department of medical microbiology, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

سید محمد جواد حسینی | seyed mohammad javad hosseini
molecular biology research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

فرشاد کاویانی | farshad kaviani
department of medical microbiology, faculty of medicine, baqiyatallah university of medical sciences,tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/887
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