Iranian Journal of Basic Medical Sciences، جلد ۱۳، شماره ۴، صفحات ۲۱۳-۲۲۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Hepatitis B Virus Surface Antigen Variants Clustered Within Immune Epitopes in Chronic Hepatitis B Carriers from Hormozgan Province, South of Iran
چکیده انگلیسی مقاله Objective(s) The aim of this study was to characterize the hepatitis B virus surface protein genotypes and sequence variations among hepatitis B virus surface antigen (HBsAg) positive chronic patients in Hormozgan province, south of Iran. Materials and Methods A total of 8 patients enrolled in this study. The surface gene was amplified and directly sequenced. Genotypes and nucleotide/amino acid substitutions were identified compared to the sequences obtained from the database. Results All strains belonged to genotype D. Overall 77 “mutations” occurred at 45 nucleotide positions, of them, 44 (57.14%) were silent (no amino acid altering) and 33 (42.86%) were missense (amino acid changing). A number of 24 (80%) out of 30 amino acid changes occurred in different immune epitopes within surface protein, of which, 9 (30%) in B cell epitopes in 7 residues (2 occurred in “a” determinant region); 8 (42.1%) in T helper epitopes in 7 residues and 7 (10%) in 4 residues inside CTL epitopes. Conclusion Hepatitis B virus genome containing mutated immune epitopes no longer could be recognized by specific T- cells of the host immune surveillance and did not enhance anti-HBs production. This could led to the progression of chronicity of hepatitis B virus infection.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مهدی نوروزی | mehdi norouzi
iranian national institute for genetic engineering and biotechnology, tehran, iran


سید علی قرشی | seyed ali ghorashi
iranian national institute for genetic engineering and biotechnology, tehran, iran


بهروز عطایی | behrooz ataei
infectious diseases and tropical medicine research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مجید یاران | majid yaran
infectious diseases and tropical medicine research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

رضا ملک زاده | reza malekzadeh
digestive disease research center, shariati hospital, tehran, iran


سید موید علویان | seyed moayyed alavian
baqiyatallah university of medical sciences, baqiyatallah research centre for gastroenterology and liver disease, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

محمد علی جودکی | mohammad ali judaki
hepatitis b molecular laboratory,department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شیوا قمری | shiva ghamari
hepatitis b molecular laboratory,department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علیرضا نمازی | alireza namazi
hepatitis b molecular laboratory,department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رامین رحیم نیا | ramin rahimnia
hepatitis b molecular laboratory,department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ابوالفضل khedive | abolfazl khedive
hepatitis b molecular laboratory,department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید محمد جزایری | seyed mohammad jazayeri
hepatitis b molecular laboratory,department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_5117.html
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