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Iranian Journal of Basic Medical Sciences، جلد ۱۴، شماره ۳، صفحات ۲۲۵-۲۳۰
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عنوان انگلیسی Polymorphisms within Exon 9, But Not Intron 8, of the Vitamin D Receptor Gene Are Associated with Asthma
چکیده انگلیسی مقاله Objective(s) Deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. Vitamin D3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. The aim of this study was to investigate the association between polymorphisms in intron 8 and exon 9 of the vitamin D receptor (VDR) and this disease. Materials and Methods This study was performed on 100 asthmatic patients and 100 healthy controls. PCR-RFLP was performed to examine polymorphisms in intron 8 and exon 9 of VDR gene. Results Our results showed a statistically significant difference in the Taq-1 evaluated genotypes of exon 9 of the VDR gene when comparing healthy patients to asthmatic patients. Conclusion Based on our results, it can be concluded that VDR and its functional polymorphisms may play an important role in the pathogenesis of asthma.
کلیدواژه‌های انگلیسی مقاله Asthma, Polymorphism, VDR
نویسندگان مقاله محمد کاظمی عرب آبادی | mohammad kazemi arababadi
department of microbiology, hematology and immunology, faculty of medicine, rafsanjan university of medical science, rafsanjan, iran|molecular medicine research center, rafsanjan university of medical sciences, rafsanjan-iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

حمید abousaidi | hamid abousaidi
department of infectious disease, faculty of medicine, rafsanjan university of medical science, rafsanjan, iran


غلامحسین حسن شاهی | gholamhossein hassanshahi
molecular medicine research center, rafsanjan university of medical sciences, rafsanjan-iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

علی اکبر پورفتح اله | ali akbar pourfathollah
department of immunology, school of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

سعید دانشمندی | saeed daneshmandi
department of immunology, school of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

وجیهه اکبرپور | vajihe akbarpour
ali-ebne abitaleb hospital, rafsanjan university of medical science, rafsanjan, iran


حمید حکیمی | hamid hakimi
department of microbiology, hematology and immunology, faculty of medicine, rafsanjan university of medical science, rafsanjan, iran


derek kennedy | derek kennedy
school of biomolecular and physical science, eskitis institute for cell and molecular therapies, griffith university nathan, queensland-australia
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4995.html
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