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Iranian Journal of Basic Medical Sciences، جلد ۱۴، شماره ۶، صفحات ۵۳۴-۵۳۹
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عنوان انگلیسی Liver Oxidative Stress after Renal Ischemia-Reperfusion Injury is Leukocyte Dependent in Inbred Mice
چکیده انگلیسی مقاله Objective(s) There are some reports in recent years indicating that renal ischemia - reperfusion (IR) induces deleterious changes in remote organs such as liver. The aim of this study was to investigate whether leukocytes have a role on the induction of oxidative stress in liver after renal IR. Materials and Methods Inbred mice in IR donor group were subjected to renal IR injury. In sham donor group the procedure was almost the same except that ischemia was not induced. Then, mice were anesthetized and blood was collected. Leukocytes were isolated from donor groups and were then transferred to intact recipient mice (from IR donor mice to IR recipient mice and from sham donor mice to sham recipient mice). Results After 24 hr, hepatic superoxide dismutase (SOD) and catalase (CAT) activities decreased significantly in recipient mice that received leukocytes from IR donor mice in comparison to recipient mice received leukocytes from sham donor mice. Conclusion These findings indicate that leukocytes are one of the mediators that induce hepatic oxidative stress after renal IR.
کلیدواژه‌های انگلیسی مقاله Leukocyte, Liver, Oxidative stress, Renal ischemia
نویسندگان مقاله حسین خواستار | hossein khastar
school of medicine, shahroud university of medical sciences, shahroud, iran


مهری کدخدایی | mehri kadkhodaee
department of physiology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حمیدرضا صادقی پور | hamid reza sadeghipour
department of physiology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بهجت سیفی | behjat seifi
department of physiology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

جمشید حاجتی | jamshid hadjati
department of immunology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عاطفه نجفی | atefeh najafi
department of physiology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

منوچهر سلیمانی | manoocher soleimani
department of medicine, university of cincinnati, msb g259 oh, united states
نشانی اینترنتی http://ijbms.mums.ac.ir/article_5052.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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