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Iranian Journal of Basic Medical Sciences، جلد ۱۵، شماره ۲، صفحات ۷۱۹-۷۲۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Folic Acid and Coenzyme Q10 Ameliorate Cognitive Dysfunction in the Rats with Intracerebroventricular Injection of Streptozotocin |
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| چکیده انگلیسی مقاله |
Objective(s) The present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme Q10 (CoQ10) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (ICV-STZ), an animal model of sporadic type of Alzheimer's disease. Materials and Methods The lesion groups were injected bilaterally with ICV-STZ (1.5 mg/kg b.wt., in normal saline). In the treated groups, rats received folic acid (4 mg/kg; i.p.) or CoQ10 (10 mg/kg; i.p.), either alone or together, for 21 days. Passive avoidance learning test was used for evaluation of learning and memory. Results The results showed that learning and memory performance was significantly impaired in the rats with ICV-STZ (P< 0.001), however CoQ10 and folic acid, either alone or together, prevented impairments significantly (P< 0.001), as there was not any significant difference between these treated lesion groups and control group. Conclusion The present results suggest that CoQ10 and folic acid have therapeutic and preventive effects on cognitive impairments in Alzheimer’s disease. |
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| نویسندگان مقاله |
حمیدرضا دهقانی دولت آبادی | hamid reza dehghani dolatabadi
department of basic sciences, isfahan payame noor university, isfahan, iran
سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)
پرهام رییسی | parham reisi
department of physiology, school of medicine, isfahan university of medical sciences, isfahan, iran|biosensor research centre, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
حجت اله علایی | hojjatallah alaei
department of physiology, school of medicine, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
حمید عزیزی ملک آبادی | hamid azizi malekabadi
department of basic sciences, islamic azad university khorasgan branch, isfahan, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
علی اصغر پیله وریان | ali asghar pilehvarian
department of basic sciences, isfahan payame noor university, isfahan, iran
سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_4843.html |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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