| چکیده انگلیسی مقاله |
The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only a minority of infected subjects. Therefore, viral infection is usually not the only cause of cancer, and further environmental and host factors, may be implicated. HTLV-I, in particular, is considered as an oncovirus cause of lymphoproliferative disease such as adult T cell leukemia/lymphoma (ATL) and disturbs the immune responses which results in HTLV-I associated meylopathy/tropical spastic parapresis (HAM/TSP). HTLV-I infection causes ATL in a small proportion of infected subjects (2-5%) following a prolonged incubation period (15-30 years) despite a strong adaptive immune response against the virus. Overall, these conditions offer a prospect to study the molecular basis of tumorgenicity in mammalian cells. In this review, the oncogencity of HTLV-I is being considered as an oncovirus in context of ATL. |
| نویسندگان مقاله |
ساناز احمدی ghezeldasht | sanaz ahmadi ghezeldasht
research centre for hiv aids, htlv and viral hepatitis, iranian academic centre for education, culture amp;amp; research acecr , mashhad branch, mashhad, iran
عباس شیردل | abbas shirdel
inflammation and inflammatory diseases research centre, medical school, mashhad university of medical science, mashhad, iran.
محمد علی عصاره زادگان | mohammad ali assarehzadegan
department of immunology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)
طاهره حسن نیا | tahereh hassannia
internal medicine dept, medical school, arak university of medical sciences, arak- iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)
حسین رحیمی | hosian rahimi
inflammation and inflammatory diseases research centre, medical school, mashhad university of medical science, mashhad, iran.
راحله میری | rahele miri
research centre for hiv aids, htlv and viral hepatitis, iranian academic centre for education, culture amp;amp; research acecr , mashhad branch, mashhad, iran
s a رحیم رضایی | s a rahim rezaee
immunology research centre, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
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