این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۵، صفحات ۷۱۹-۷۲۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Production, Quality Control and Biological Evaluation of 166Ho-PDTMP as a Possible Bone Palliation Agent
چکیده انگلیسی مقاله Objective(s):In this study, 166Ho-1,2-propylene di-amino tetra(methy1enephosphonicAcid) (166Ho-PDTMP) complex was prepared as a bone palliation agent. Materials and Methods:The complex was successfully prepared using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 n.cm-2.s-1) of natural Ho(NO3)3 samples followed by radiolabeling and stability studies. Biodistribution in wild type rats was also peformed. Results: The complex was prepared with thespecific activity of 278 GBq/mg and high radiochemical purity (>99%, checked by ITLC). 166Ho-PDTMP complex was stabilized in the final preparation and in the presence of human serum (>90%) up to 72 hr. The biodistribution of 166Ho-PDTMP in wild-type rats demonstrated significant bone uptake was up to 48 hr compared to 166HoCl3. Conclusion: The produced 166Ho-PDTMP properties suggest a possible new bone palliative therapeutic to overcome the metastatic bone pains.
کلیدواژه‌های انگلیسی مقاله Biodistribution 166Ho PDTMP Radiopharmaceutical Therapy
نویسندگان مقاله سمانه ذوالقدری | samaneh zolghadri
radiopharmaceutical research amp;amp; development laboratory rrdl , nuclear science and technology research institute nstri , tehran, iran 2 faculty of energy engineering and physics, amirkabir university of technology, tehran, iran

سازمان اصلی تایید شده: دانشگاه صنعتی امیرکبیر (Amirkabir university of technology)

امیررضا جلیلیان | amir reza jalilian
radiopharmaceutical research amp;amp; development laboratory rrdl , nuclear science and technology research institute nstri , tehran, iran 2 faculty


زهره ناصری | zohreh naseri
radiopharmaceutical research amp;amp; development laboratory rrdl , nuclear science and technology research institute nstri , tehran, iran


حسن یوسف نیا | hassan yousefnia
radiopharmaceutical research amp;amp; development laboratory rrdl , nuclear science and technology research institute nstri , tehran, iran


علی بهرامی سامانی | ali bahrami samani
radiopharmaceutical research amp;amp; development laboratory rrdl , nuclear science and technology research institute nstri , tehran, iran


محمد قنادی مراغه | mohammad ghannadi maragheh
radiopharmaceutical research amp;amp; development laboratory rrdl , nuclear science and technology research institute nstri , tehran, iran


حسین آفریده | hossein afarideh
faculty of energy engineering and physics, amirkabir university of technology, tehran, iran

سازمان اصلی تایید شده: دانشگاه صنعتی امیرکبیر (Amirkabir university of technology)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_786.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات