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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۴، صفحات ۳۴۳-۳۴۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The prevention and treatment effects of egg yolk high density lipoprotein on the formation of atherosclerosis plaque in rabbits |
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| چکیده انگلیسی مقاله |
Objective(s): Atherosclerosis is the main leading cause of cardiovascular diseases. The purpose of this study was to assess the potential preventive effect of egg yolk HDL on the atherosclerosis plaque formation. Materials and Methods: Thirty rabbits were divided into five groups: A; normal diet, B; hyper-cholesterolemic diet, C; hypercholesterolemic + 400 mg/kg egg yolk HDL D; hypercholesterolemic +100 mg/kg egg yolk HDL and E; 200 mg/kg egg yolk HDL. At the end of the experiment, the lipid profiles were measured by spectrophotometric method. The histological sections of thoracic aorta also were taken and analyzed under light microscope. Results: At the end of the 2nd and the 4th weeks, there was a significant increase of cholesterol level in groups B, C, and D compared to group A (P< 0.05). Following HDL treatment, triglyceride (TG) levels increased significantly versus group A and also the TG level decreased significantly in group C, D, and E versus group B (P< 0.01). Egg yolk HDL significantly increased HDL-C in groups C, D, and E (P< 0.01) compared to groups A and B (P< 0.05). The surface area of the atherosclerotic plaque was increased significantly in group B versus group A (P< 0.001). Egg yolk HDL consumption reduced the plaque size significantly (P< 0.001). Conclusion: Our findings indicated that treatment with egg yolk HDL increased serum HDL-C and decreased atherosclerotic plaque size in rabbits.Thus, egg yolk HDL may be considered as an anti-atherosclerotic treatment for cardiovascular diseases. |
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| کلیدواژه‌های انگلیسی مقاله |
Atherosclerosis, Cholesterol, Egg yolk, HDL, Rabbit |
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| نویسندگان مقاله |
شیما افتخار | shima eftekhar
neurocognitive research center and department of physiology, college of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
حیدر پارسایی | heidar parsaei
department of pharmacology, college of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
زکیه کشاورزی | zakieh keshavarzi
department of physiology, college of medicine, north khorasan university of medical sciences, bojnourd, iran
عباس طباطبایی یزدی | abbas tabatabaei yazdi
department of pathology, college of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
موسی الرضا حاج زاده | mosa al reza hadjzadeh
neurocognitive research center and department of physiology, college of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
علی اکبر رجب زاده | aliakbar rajabzadeh
department of anatomy and cell biology, college of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
سینا امید ملایری | sina omid malayeri
student research committee, school of pharmacy, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_4282.html |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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