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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۲، صفحات ۲۲۱-۲۲۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats |
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| چکیده انگلیسی مقاله |
Objective(s):Paclitaxel is a potent chemotherapy agent with severe side effects, including allergic reactions, cardiovascular problems, complete hair loss, joint and muscle pain, which may limit its use and lower its efficiency. The cardioprotective effect of royal jelly was investigated on paclitaxel-induced damages. Materials and Methods:Adult male Wistar rats were divided into control and test groups (n=8). The test group was assigned into five subgroups; 4 groups, along with paclitaxel administration (7.5 mg/kg BW, weekly), received various doses of royal jelly (50, 100, and 150 mg/kg BW) for 28 consecutive days. The last group received only royal jelly at 100 mg/kg. In addition to oxidative and nitrosative stress biomarkers, the creatine kinase (CK-BM) level was also determined. To show the cardioprotective effect of royal jelly on paclitaxel-induced damages, histopathological examinations were conducted. Results:Royal jelly lowered the paclitaxel-elevated malondialdehyde and nitric oxide levels in the heart. Royal jelly could also remarkably reduce the paclitaxel-induced cardiac biomarker of creatine kinase (CK-BM) level and pathological injuries such as diffused edema, hemorrhage, congestion, hyaline exudates, and necrosis. Moreover, royal jelly administration in a dose-dependent manner resulted in a significant (P<0.05) increase in the paclitaxel-reduced total antioxidant capacity. Conclusion:Our data suggest that the paclitaxel-induced histopathological and biochemical alterations could be protected by the royal jelly administration. The cardioprotective effect of royal jelly may be related to the suppression of oxidative and nitrosative stress. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
حسن ملکی نژاد | hassan malekinejad
department of pharmacology and toxicology, faculty of pharmacy, urmia university of medical sciences, urmia, iran|department of pharmacology and toxicology, faculty of veterinary medicine, university of urmia, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)
سیما احسن | sima ahsan
department of pharmacology and toxicology, faculty of veterinary medicine, university of urmia, iran
سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)
فاطمه دلخوش کسمایی | fatemeh delkhosh kasmaie
department of pathology, faculty of veterinary medicine, university of urmia, iran
سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)
هادی چراغی | hadi cheraghi
department of clinical pathology, faculty of veterinary medicine, tehran university, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
علی رضایی گل میشه | ali rezaei golmisheh
department of pharmacology and toxicology, faculty of veterinary medicine, university of urmia, iran
سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)
حامد جانباز acyabar | hamed janbaz acyabar
department of pharmacology and toxicology, faculty of veterinary medicine, university of urmia, iran
سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_6549.html |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Short Communications |
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