این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۱۰، صفحات ۱۱۱۴-۱۱۲۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anti-hyperglycaemic and antioxidant effects of Bidens tripartita and quantitative analysis on its active principles
چکیده انگلیسی مقاله Objective(s): Bidens species are used for their antidiabetic properties traditionally in many countries. Aim of this study is to evaluate hypoglycaemic and antidiabetic activity of Bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. Materials and Methods: Hypoglycaemic effects of B. tripartita extract and its sub-extracts were investigated in normal and glucose-hyperglycaemic rats. Streptozotocin induced diabetic rats were used to examine antidiabetic activity of the extract and its sub-extracts after acute and sub-acute administration. Additionally, in vitro enzyme inhibitory and antioxidant activities were evaluated. HPLC analyses were carried out to determine the active constituents of the extract and its sub-extracts. Results: Through in vivo bioactivity-guided fractionation process, ethyl acetate and n-buthanol sub-extracts were found to have potent antidiabetic activity. In vitro enzyme inhibitory activities of the same sub-extracts were found to be potent. The highest total phenol, flavonoid contents and radical scavenging activity was determined in ethyl acetate sub-extract. According to LC-MS analyses, chlorogenic acid, luteolin and 7-O-glucoside of luteolin (cynaroside) were determined as the main components of the active sub-extracts. Conclusion: According to our results, B. tripartita has potent antidiabetic activity and its active constituents might be beneficial for diabetes and its complications. 
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله nilüfer orhan | nilüfer orhan
department of pharmacognosy, faculty of pharmacy, gazi university, 06330, etiler, ankara, turkey


ülkü gökçen içöz | ülkü gökçen içöz
republic of turkey social security institution, 06520, balgat, ankara, turkey


levent altun | levent altun
department of pharmacognosy, faculty of pharmacy, ankara university, 06500, tandogan, ankara, turkey


مصطفی اصلان | mustafa aslan
department of pharmacognosy, faculty of pharmacy, gazi university, 06330, etiler, ankara, turkey
نشانی اینترنتی http://ijbms.mums.ac.ir/article_7737.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات