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Journal of Arthropod-Borne Diseases، جلد ۱۱، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Gas Chromatography, GC/Mass Analysis and Bioactivity of Essential Oil from Aerial Parts of Ferulago trifida: Antimicrobial, Antioxidant, AChE Inhibitory, General Toxicity, MTT assay and Larvicidal Activities
چکیده انگلیسی مقاله Background: We aimed to investigate different biological properties of aerial parts essential oil of Ferulago trifida Boiss and larvicidal activity of its volatile oils from all parts of plant. Methods: Essential oil was prepared by steam distillation and analyzed by Gas chromatography and GC/Mass. Anti­oxidant, antimicrobial, cytotoxic effects and AChE inhibitory of the oil were investigated using DPPH, disk diffusion method, MTT assay and Ellman methods. Larvicidal activity of F. trifida essential oil against malaria vector Anoph­eles stephensi was carried out according to the method described by WHO. Results: In GC and GC/MS analysis, 58 compounds were identified in the aerial parts essential oil, of which E-ver­benol (9.66%), isobutyl acetate (25.73%) and E-β-caryophyllene (8.68%) were main compounds. The oil showed (IC 50 = 111.2µg/ml) in DPPH and IC50= 21.5 mg/ml in the investigation of AChE inhibitory. Furthermore, the oil demonstrated toxicity with (LD 50 = 1.1µg/ml) in brine shrimp lethality test and with (IC 50 = 22.0, 25.0 and 42.55 µg/ml) on three cancerous cell lines (MCF-7, A-549 and HT-29) respectively. LC 50 of stem, root, aerial parts, fruits, and flowers essential oils against larvae of An. stephensi were equal with 10.46, 22.27, 20.50, 31.93 and 79.87ppm respectively. In antimicrobial activities, essential oil was effective on all specimens except Escherichia coli , Asper­gillus niger and Candida albicans. Conclusion: The essential oil showed moderate antioxidant activity, strong antimicrobial properties and good toxic effect in brine shrimp test and MTT assay on three cancerous cell lines.
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نویسندگان مقاله سعید توکلی | saeed tavakoli
dept. of medical entomology and vector control, school of public health, tehran university of medical sciences, tehran, iran dept. of environmental chemical pollutants and pesticides, institute for environmental research, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسن وطن دوست | hassan vatandoost
medicinal plants research center, institute of medicinal plants, acecr, karaj, iran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

رضا زیدآبادی نژاد | reza zeidabadinezhad
medicinal plants research center, institute of medicinal plants, acecr, karaj, iran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

رضا حاجی آقایی | reza hajiaghaee
dept. of pharmacognosy, faculty of pharmacy and medicinal plant research center, tehran university of medical sciences, tehran, iran medicinal plants research center, institute of medicinal plants, acecr, karaj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عباس حاجی آخوندی | abbas hadjiakhoondi
dept. of medical entomology and vector control, school of public health, tehran university of medical sciences, tehran, iran dept. of environmental chemical pollutants and pesticides, institute for environmental research, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا عبایی | mohammad reza abai
dept. of pharmacognosy, faculty of pharmacy and medicinal plant research center, tehran university of medical sciences, tehran, iran medicinal plants research center, institute of medicinal plants, acecr, karaj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نرگس یاسا | narguess yassa


نشانی اینترنتی http://jad.tums.ac.ir/index.php/jad/article/view/735
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زبان مقاله منتشر شده en
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