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Journal of Arthropod-Borne Diseases، جلد ۱۱، شماره ۲، صفحات ۳۱۵-۰
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عنوان انگلیسی Synthesis and Chemometrics of Thymol and Carvacrol Derivatives as Larvicides against Aedes aegypti
چکیده انگلیسی مقاله Background : Thymol and carvacrol have previously demonstrated larvicidal activity against Aedes aegypti (Diptera: Culicidae). In view of this fact, it was of our interest to obtain synthetic derivatives and evaluate their larvicidal ac­tivity on Ae. aegypti larvae. Methods : Structural modifications were performed on thymol and carvacrol in an effort to understand the functional groups necessary for modulating their activities and to lead possibly to more effective larvae control agents. The derivatives were further subjected to SAR and computational studies (molecular modeling and chemometric tools (CPCA and PCA)) to extract structural information regarding their larvicidal properties. Field collected and Rocke­feller populations of Ae. aegypti were used. Results : Carvacrol and thymol exhibited LC 50 of 51 and 58ppm for field collected larvae, respectively. Carvacrol derivatives exhibited LC 50 ranging from 39 to 169ppm, while thymol derivatives exhibited LC 50 ranging from 18 to 465ppm. Substitution of the acidic proton of carvacrol by esters, ethers, and acetic acid resulted in either mainte­nance or reduction of potency. Conclusion : Thymol derivatives were, to a certain extent, more efficient larvicides against Ae. aegypti than carvacrol derivatives, particularly to Rockefeller larvae. The chemometrics tools applied in this study showed that the inde­pendent variables indicate a mixed profile. Nevertheless, hydrophobic interactions increased the larvicidal activity.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله viviane باروس سیلوا | viviane barros silva
medicinal chemistry laboratory, pharmacy department, federal university of sergipe, são cristóvão, brazil


daniele لیما travassos | daniele lima travassos
nuclear magnetic resonance laboratory, chemistry department, federal university of paraná, curitiba, brazil


angelita nepel | angelita nepel
nuclear magnetic resonance laboratory, chemistry department, federal university of paraná, curitiba, brazil


اندرسون barison | andersson barison
chemistry department, institute of sciences, federal university of amazonas, manaus, brazil


emmanoel vilaça costa | emmanoel vilaça costa
biotechnology center, federal university of paraíba, campus i, joão pessoa, brazil


luciana scotti | luciana scotti
biotechnology center, federal university of paraíba, campus i, joão pessoa, brazil


مارکوس tulius scotti | marcus tulius scotti
laboratory of synthesis and delivery of molecules, biological sciences department, state university of paraíba, joão pessoa, paraiba, brazil


rancisco jaime bezerra mendonça junior | rancisco jaime bezerra mendonça junior
parasitology and tropical entomology laboratory, morphology department, federal university of sergipe, são cristóvão, brazil


roseli la corte دوست سانتوز | roseli la corte dos santos
medicinal chemistry laboratory, pharmacy department, federal university of sergipe, são cristóvão, brazil


sócrates cabral de holanda cavalcanti | sócrates cabral de holanda cavalcanti


نشانی اینترنتی http://jad.tums.ac.ir/index.php/jad/article/view/598
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/77/article-77-429949.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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