Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۱۸، شماره ۳، صفحات ۲۰۷-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma
چکیده انگلیسی مقاله Statement of the Problem: Squamous cell carcinoma (SCC) is the most frequent oral cancer whose 5-year survival rate is 80% for early-detected lesions and nearly 30-50% for advanced lesions. Early detection of oral cancers and precancerous lesions can improve the patient’s survival and decrease the morbidity. Purpose: This study aimed to evaluate and compare the Ki-67 and MCM3 expression in cytologic smear of oral SCC (OSCC). Materials and Method: We examined 48 oral brush biopsies including 28 OSCC and 20 healthy non-smoking samples. Immunocytochemistry staining was performed for Ki-67 andMCM3 by using an EnVision-labeled peroxidase system, and labeling index (LI) was calculated. Results: Out of 28 OSCC cases, 27(96.4%) cases contained MCM3 positive cells and 22(78%) cases contained Ki-67 positive cells. All normal mucosa were Ki-67 and MCM3 negative. MCM3 and Ki-67 LI were significantly higher in OSCC than normal mucosa ( p < 0.001). MCM3 LI was significantly higher than Ki-67 LI in OSCC group ( p < 0.001). Conclusion: Immunocytologic evaluation of Ki-67 and MCM3 can be used for early detection of OSCC. Furthermore, MCM3 may be a more sensitive cytologic biomarker than Ki-67 in SCC patients. Keywords ● Squamous Cell Carcinoma ● Cytology ● Biopsy ● Ki-67 antigen ● Minichromosome Maintenance Complex Component 3
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فهیمه رضازاده | fahimeh rezazadeh
dept. of oral amp;amp; maxillofacial medicine, school of dentistry, shahrekord university of medical sciences, shahrekord, iran.


راحله ابراهیمی | rahele ebrahimi
dept. of oral amp;amp; maxillofacial medicine, school of dentistry, shahrekord university of medical sciences, shahrekord, iran.


آزاده اندیشه تدبیر | azadeh andisheh tadbir
oral and dental disease research center, dept. of oral amp;amp; maxillofacial pathology, school of dentistry, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمد جواد اشرف | mohammad javad ashraf
dept. of pathology, school of medicine, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

بیژن خادمی | bijan khademi
otolaryngology research center, dept. of otorhinolaryngology, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1525
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/331/article-331-426953.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات