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Iranian Journal of Psychiatry، جلد ۱۲، شماره ۳، صفحات ۱۵۴-۱۶۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Comparison of Saffron and Fluvoxamine in the Treatment of Mild to Moderate Obsessive- Compulsive Disorder: A Double Blind, Randomized Clinical Trial |
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| چکیده انگلیسی مقاله |
Objective: There are different pathophysiological mechanisms for obsessive- compulsive disorder (OCD) as suggested by the serotonergic, dopaminergic, and glutamatergic hypotheses. The present study aimed at comparing the efficacy and safety of saffron (stigma of Crocus sativus) and fluvoxamine in the treatment of mild to moderate obsessive- compulsive disorder. Method: In this study, 50 males and females, aged 18 to 60 years, with mild to moderate OCD, participated. The patients were randomly assigned to receive either saffron (30 mg/day, 15 mg twice a day) or fluvoxamine (100 mg/day) for 10 weeks. Using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Adverse Event Checklist, we assessed the patients at baseline, and at the second, fourth, sixth, eighth, and tenth week. Finally, the data were analyzed using general linear repeated measures. Results: In this study, 46 patients completed the trial. General linear repeated measures demonstrated no significant effect for time-treatment interaction on the Y-BOCS total scores [F (2.42, 106.87) = 0.70, P = 0.52], obsession Y-BOCS subscale scores [F (2.47, 108.87) = 0.77, p = 0.49], and compulsion Y-BOCS subscale scores [F (2.18, 96.06) = 0.25, P = 0.79]. Frequency of adverse events was not significantly different between the 2 groups. Conclusion: Our findings suggest that saffron is as effective as fluvoxamine in the treatment of patients with mild to moderate OCD. |
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| نویسندگان مقاله |
سوفیا اصالت منش | sophia esalatmanesh
department of psychiatry, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
مجتبی biuseh | mojtaba biuseh
احمد علی نوربالا | ahmad ali noorbala
psychosomatic research center, imam hospital, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سید علی مصطفوی | seyed ali mostafavi
psychiatry and psychology research center, roozbeh hospital, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
فرزین رضایی | farzin rezaei
بیتا مسگرپور | bita mesgarpour
national institute for medical research development nimad , tehran, iran.
سازمان اصلی تایید شده: مرکز ملی تحقیقات علوم پزشکی کشور (National institute for medical research development)
پیام محمدی نژاد | payam mohammadinejad
psychiatry and psychology research center, roozbeh hospital, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
شاهین آخوندزاده | shahin akhondzadeh
psychiatry and psychology research center, roozbeh hospital, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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| نشانی اینترنتی |
http://ijps.tums.ac.ir/index.php/ijps/article/view/1115 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/64/article-64-413199.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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