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Journal of Kerman University of Medical Sciences، جلد ۱۸، شماره ۲، صفحات ۱۴۴-۱۵۳
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عنوان انگلیسی The Effect of Flavonoid Naringenin on Contractile Response of Thoracic Aorta Isolated from Diabetic Rats
چکیده انگلیسی مقاله Background & Aims: Considering increasing incidence of cardiovascular disorders in diabetes mellitus and some evidence on antioxidant and antidiabetic potentials of naringenin, this study was conducted to evaluate the beneficial effects of 6-week administration of naringenin on contractile reactivity of isolated thoracic aorta in diabetic rats. Methods: Male Wistar rats were divided into control, naringenin-treated control, diabetic and glibenclamide-treated, and naringenin-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was administered (60 mg/Kg). Naringenin (10 mg/kg) was administered i.p. one week after diabetes induction in every other day intervals for 6 weeks. Serum glucose level was measured before naringeninadministration and at 6th week. Finally, contractile reactivity of thoracic aortic rings to KCl and phenylephrine (PE) was cumulatively determined. Results: Serum glucose level at week 6 showed a significant decrease in naringenin-treated diabetic group compared to diabetics (P< 0.01). In addition, naringenin-treated diabetic group showed a significantly lower contraction to PE (P< 0.05) as compared to diabetic group and such significant reduction was also observed for KCl (P< 0.05). Meanwhile, there was also a significant difference between control and naringenin-treated control groups regarding their contractile reactivity to PE (P< 0.05). Conclusion: Subchronic administration of naringenin for 6 weeks could exert an anti-hyperglycemic effect and lowers contractile responsiveness of thoracic aorta rings to KCl and phenylephrine.
کلیدواژه‌های انگلیسی مقاله Naringenin, diabetes mellitus, Aorta, Contractility
نویسندگان مقاله f فلاحی |
assistant professor, department of cardiology, school of medicine, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

m روغنی |
professor, department of physiology, school of medicine and medicinal plant research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

k نصری |
student of medicine, school of medicine, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

نشانی اینترنتی http://jkmu.kmu.ac.ir/article_16575_20acf75916a4ba181e14169f76531edd.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-405069.pdf
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زبان مقاله منتشر شده en
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