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Journal of Kerman University of Medical Sciences، جلد ۲۳، شماره ۶، صفحات ۷۱۴-۷۲۶
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Curcumin Protects Mice Testicular Tissue against the Adverse Effects of Sodium Arsenite: A Stereological Study
چکیده انگلیسی مقاله Background & Aims: Sodium arsenite, an environmental pollutant, produces free radicals with harmful effects on the reproductive system. The aim of this study was to investigate the effect of curcumin, as a strong antioxidant, on the testis tissue and spermatogenic cell population in mice treated with sodium arsenite. Methods: In this experimental study, Adult male NMRI mice were randomly divided into the 5 groups (n=6): control, sodium arsenite (5mg/kg/day), curcumin (15mg/kg/day), sodium arsenite+curcumin and DMSO as vehicle. After 5 weeks of treatment (through intraperitoneal ingection), animals right testis were removed, fixed, sectioned, stained (using heiden hain azan method) and stereologically studied. Data were analyzed using one-way ANOVA and Tuckey's test and the means were considered significantly different at p< 0.05.‌ Result: A significant decrease in the mean volume (P< 0.05) and diameter (P< 0.001) of seminiferous tubules, height of the germinal epithelium (P< 0.01), thickness of the basement membrane (P< 0.001) and the number of spermatocytes and spermatids (p< 0.001) and a significant increase in the mean volume of the interstitial tissue was observed in the sodium arsenite group compared to the control ones (p< 0.05). The above parameters were significantly compensated to the control level in the sodium arsenite+curcumin group. Conclusions: Curcumin can compensate the harmful effects of sodium arsenite on the testicular tissue and spermatogenic cell populations in adult mice. Therefor, it is suggested as a supplement in the case of arsenite intoxication.
کلیدواژه‌های انگلیسی مقاله Curcumin, mice, Sodium arsenate, Stereology, Testis
نویسندگان مقاله ملک سلیمانی مهرنجانی | soleimani mehranjani
professor of histology and embryology, department of biology, faculty of science, arak university, arak, iran
سازمان اصلی تایید شده: دانشگاه اراک (Arak university)

نجمه حاتمی کیا |
masters of developmental cell biology, department of biology, faculty of science, arak university, arak, iran
سازمان اصلی تایید شده: دانشگاه اراک (Arak university)

سمیرا نادری نورعینی | naderi noreini
masters of developmental cell biology, department of biology, faculty of science, arak university, arak, iran
سازمان اصلی تایید شده: دانشگاه اراک (Arak university)

نشانی اینترنتی http://jkmu.kmu.ac.ir/article_41264_48acf403e867d7de0f7b4628fb9d9a0c.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-404752.pdf
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زبان مقاله منتشر شده en
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