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Journal of Kerman University of Medical Sciences، جلد ۲۴، شماره ۱، صفحات ۵۰-۵۷
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عنوان انگلیسی The Association of 4G/5G Polymorphism of PAI-1-675 Gene with Clinicopathologic Features of Thyroid Tumors in Iranian Azeri Turkish Patients
چکیده انگلیسی مقاله Background: Due to the lack of information about the role of 4G/5G polymorphism of PAI-1 Gene in susceptibility to thyroid tumors, this study was performed to evaluate the potential effects of this polymorphism on clinicopathologic features of thyroid tumors in Iranian Azeri Turkish patients. Methods:In this case-control study, 90 patients with thyroid tumors who were not blood relatives and their PAI-1 4G/5G polymorphism had been determined in the previous study, were included. Results: All clinicopathologic features of thyroid tumor related to PAI-1 4G/5G polymorphism that affect the severity of disease were studied. The results show that T1 tumor size (4G/4G, P = 0.019; 4G/5G, P = 0.021) in patients with/without these features was significantly different. Conclusion: Data showed a protective role for 4G allele versus 5G and 4G/4G versus 5G/5G against the development of thyroid tumors in Azeri Turkish ethnic group.
کلیدواژه‌های انگلیسی مقاله Polymorphism, Thyroid Tumors, PAI-1 Gene
نویسندگان مقاله ناصر پولادی |
assistant professor, department of biology, faculty of sciences, azarbaijanshahidmadani university, tabriz, iran

مهدیه یونسی |
master of genetics, department of animal biology, faculty of natural sciences, tabriz university, tabriz, iran
سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

محمدعلی حسینپورفیضی |
professor of radiobiology, department of animal biology, faculty of natural sciences, tabriz university, tabriz, iran
سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://jkmu.kmu.ac.ir/article_42497_3f24b0283eb3355b4fbf3665b6684504.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-404743.pdf
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